自闭症谱系障碍学龄前儿童的生物标志物:全脑组织成分体积、智力评分、ADOS-CSS、首次造字年龄和开始行走年龄的定量分析。

IF 6.1 2区 医学 Q1 PEDIATRICS World Journal of Pediatrics Pub Date : 2024-10-01 Epub Date: 2024-03-25 DOI:10.1007/s12519-024-00800-7
Xiang Zhou, Wu-Sheng Lin, Feng-Yun Zou, Shuang-Shuang Zhong, Ya-Yin Deng, Xiao-Wen Luo, Li-Shan Shen, Shi-Huan Wang, Ruo-Mi Guo
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引用次数: 0

摘要

背景:学龄前是干预自闭症谱系障碍(ASD)儿童的关键时期;因此,我们分析了学龄前ASD儿童的脑组织成分体积(BTCV)和临床指标,以确定用于早期筛查的新生物标志物:方法:我们回顾性地纳入了80名患有ASD的学龄前儿童(3-6岁)。采用合成磁共振成像(SyMRI)技术获得全脑髓鞘含量(MyC)、白质(WM)、灰质(GM)、脑脊液(CSF)和非WM/GM/MyC/CSF脑成分体积。此外,还收集了临床数据,如智力评分、自闭症诊断观察表校准严重程度评分、首次产生单字的年龄(AFSW)、首次产生短语的年龄(AFP)和开始行走的年龄(AWO)。评估了 BTCV 与临床数据之间的相关性,并通过回归模型评估了 BTCV 对临床数据的影响:结果:WM 和 GM 容量与智力评分呈正相关(均为 P 结论:BTCV 与智力评分呈正相关:本研究揭示了WM和GM体积与智力评分之间的正相关性。全脑 MyC 影响学龄前 ASD 儿童的 AFSW、AFP 和 AWO。通过 SyMRI 对 BTCVs 进行无创量化,发现了一种新的可视化和可量化的生物标志物(异常 MyC),可用于学龄前儿童 ASD 的早期筛查。
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Biomarkers of preschool children with autism spectrum disorder: quantitative analysis of whole-brain tissue component volumes, intelligence scores, ADOS-CSS, and ages of first-word production and walking onset.

Background: Preschooling is a critical time for intervention in children with autism spectrum disorder (ASD); thus, we analyzed brain tissue component volumes (BTCVs) and clinical indicators in preschool children with ASD to identify new biomarkers for early screening.

Methods: Eighty preschool children (3-6 years) with ASD were retrospectively included. The whole-brain myelin content (MyC), white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), and non-WM/GM/MyC/CSF brain component volumes were obtained using synthetic magnetic resonance imaging (SyMRI). Clinical data, such as intelligence scores, autism diagnostic observation schedule-calibrated severity scores, age at first production of single words (AFSW), age at first production of phrases (AFP), and age at walking onset (AWO), were also collected. The correlation between the BTCV and clinical data was evaluated, and the effect of BTCVs on clinical data was assessed by a regression model.

Results: WM and GM volumes were positively correlated with intelligence scores (both P < 0.001), but WM and GM did not affect intelligence scores (P = 0.116, P = 0.290). AWO was positively correlated with AFSW and AFP (both P < 0.001). The multivariate linear regression analysis revealed that MyC, AFSW, AFP, and AWO were significantly different (P = 0.005, P < 0.001, P < 0.001).

Conclusions: This study revealed positive correlations between WM and GM volumes and intelligence scores. Whole-brain MyC affected AFSW, AFP, and AWO in preschool children with ASD. Noninvasive quantification of BTCVs via SyMRI revealed a new visualizable and quantifiable biomarker (abnormal MyC) for early ASD screening in preschool children.

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来源期刊
World Journal of Pediatrics
World Journal of Pediatrics 医学-小儿科
CiteScore
10.50
自引率
1.10%
发文量
592
审稿时长
2.5 months
期刊介绍: The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics. We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
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