与非综合征唇腭裂相关的原发性和继发性缺陷模式:肯尼亚人口的流行病学分析。

IF 1.3 4区 医学 Q3 PEDIATRICS Congenital Anomalies Pub Date : 2024-03-26 DOI:10.1111/cga.12564
Martin Kamau, Krishan Sarna, Symon Guthua, Khushboo Jayant Sonigra, Paul Kimani
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引用次数: 0

摘要

唇腭裂畸形给个人和家庭带来沉重负担,尤其是在低收入社区。然而,对这些畸形在肯尼亚的模式和分布的全面了解仍然有限。这项回顾性横断面研究分析了肯尼亚 BelaRisu 基金会登记处的 647 份临床记录,时间跨度为 2018-2022 年。经过细致的记录核实和数据提取后,采用裂隙模式建模对每个病例进行了分析。数据被导入 SPSS 29.0 版,并计算了描述性统计,包括平均值、范围、频率、百分比和标准偏差。此外,还进行了性别对比分析。研究结果显示,与肯尼亚以往的研究相比,男性的平均发病年龄更高,而且男性更容易患唇腭裂。值得注意的是,各省的病例分布存在差异。唇裂是最常见的原发性缺陷,而腭瘘则是最常见的继发性缺陷。有趣的是,虽然有些结果与全球趋势一致,但有些结果却与现有文献有很大出入,值得进一步探讨和研究。这些发现揭示了肯尼亚唇腭裂畸形的独特模式和分布情况,强调了有针对性的干预措施和支持系统的必要性。
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Patterns of primary and secondary defects associated with non-syndromic cleft lip and palate: An epidemiological analysis in a Kenyan population

Cleft lip and palate deformities substantially burden individuals and families, particularly in low-income communities. However, a comprehensive understanding of the patterns and distribution of these deformities in Kenya remains limited. This retrospective cross-sectional study analyzed 647 clinical records from the BelaRisu Foundation registry in Kenya, spanning 2018–2022. After meticulous record verification and data extraction, cleft pattern modeling was used to analyze each case. Data were imported to SPSS version 29.0 and descriptive statistics were calculated, which included means, ranges, frequencies, percentages, and standard deviations. Additionally, a comparative analysis between genders was conducted. The findings revealed a higher average age of presentation compared with previous studies in Kenya, along with a greater susceptibility of males to cleft lip and palate defects overall. Noteworthy disparities in case distribution across provinces were observed. Cleft lip emerged as the most observed primary defect, while palatal fistulae constituted the most frequent secondary defect. Interestingly, while some results aligned with global trends, others diverged significantly from the existing literature, warranting further exploration and investigation. These findings shed light on the unique patterns and distribution of cleft lip and palate deformities in Kenya, highlighting the need for targeted interventions and support systems.

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来源期刊
Congenital Anomalies
Congenital Anomalies PEDIATRICS-
自引率
0.00%
发文量
49
审稿时长
>12 weeks
期刊介绍: Congenital Anomalies is the official English language journal of the Japanese Teratology Society, and publishes original articles in laboratory as well as clinical research in all areas of abnormal development and related fields, from all over the world. Although contributions by members of the teratology societies affiliated with The International Federation of Teratology Societies are given priority, contributions from non-members are welcomed.
期刊最新文献
Issue Information Acknowledgement Acoustic evaluation of voice signal distortion by videoconferencing platforms and devices used in telepractice for cleft palate Genitourinary and craniofacial/cervicothoracic anomalies in a neonate with in-utero mycophenolate mofetil exposure Congenital cytomegalovirus and pulmonary hypertension
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