骨骼肌消耗对接受阿扎胞苷治疗的骨髓增生异常综合征患者的影响

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-28 DOI:10.3390/hematolrep16010012

Eri Takada, Nobuhiko Nakamura, Yuto Kaneda, Kenji Fukuno, Shin Lee, Kei Fujita, Tetsuji Morishita, Yoshikazu Ikoma, Takuro Matsumoto, Hiroshi Nakamura, Junichi Kitagawa, Nobuhiro Kanemura, Senji Kasahara, Takeshi Hara, Hisashi Tsurumi, Masahito Shimizu

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引用次数: 0

摘要

背景：阿扎胞苷（AZA）是治疗高危骨髓增生异常综合征（MDS）患者的标准疗法。骨骼肌耗竭（SMD）与血液恶性肿瘤的预后有关，本研究调查了骨骼肌耗竭对接受阿扎胞苷治疗的 MDS 患者临床病程的影响：这项回顾性观察研究包括 50 名接受 AZA 治疗的 MDS 患者。采用骨骼肌指数（SMI）对肌肉质量进行评估，SMI是CT图像上第三腰椎处肌肉质量的面积除以身高的平方：入组患者中有 39 名男性，中位年龄为 69.5 岁。27名患者（20名男性和7名女性）出现了SMD。SMD组患者的中位生存期为13.4个月，非SMD组患者的中位生存期为15.2个月，无明显差异，反应率或严重非血液学毒性与是否存在SMD无明显关联。相比之下，SMD组出现3-4级贫血和血小板减少的频率明显高于非SMD组。在接受AZA治疗的MDS患者中，SMD与严重贫血和血小板减少有关：结论：骨骼肌质量下降可能预示着接受 AZA 治疗的 MDS 患者会出现严重的血液学毒性。

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Impact of Skeletal Muscle Depletion on Patients with Myelodysplastic Syndrome Treated with Azacitidine.

Background: Azacitidine (AZA) is the standard treatment for patients with high-risk myelodysplastic syndromes (MDS). The impact of skeletal muscle depletion (SMD), which is associated with outcomes of hematological malignancies, on the clinical course of MDS patients treated with AZA was investigated.

Methods: This retrospective, observational study included 50 MDS patients treated with AZA. Muscle mass was evaluated using the skeletal muscle index (SMI), which is the area of muscle mass at the third lumbar vertebra on CT images divided by the square of the height.

Results: Of the enrolled patients, 39 were males, and their median age was 69.5 years. Twenty-seven (20 male and 7 female) patients showed SMD. The median survival was 13.4 months in the SMD group and 15.2 months in the non-SMD group, with no significant difference and no significant association between the response rate or severe non-hematological toxicities and the presence of SMD. By contrast, grade 3-4 anemia and thrombocytopenia were significantly more frequent in the SMD group than in the non-SMD group. SMD was associated with severe anemia and thrombocytopenia in MDS patients treated with AZA.

Conclusion: Reduced skeletal muscle mass may predict severe hematological toxicity in MDS patients treated with AZA.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.