肩胛原发性骨淋巴瘤

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-28 DOI:10.3390/hematolrep16010011
Josip Lovaković, Inga Mandac Smoljanović, Andro Matković, Tomislav Smoljanović
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引用次数: 0

摘要

肩胛原发性骨淋巴瘤是一种罕见的肿瘤,通常会引起局部疼痛。这位患者的小指和无名指出现麻痹、刺痛、麻木和水肿已有两年之久。这名 45 岁的男子接受了手掌、肘部和颈部的多项放射学和神经学评估,然后拍片发现左肩有肿瘤。确诊为弥漫大B细胞淋巴瘤后,患者开始接受利妥昔单抗、环磷酰胺、多柔比星、长春新碱和甲基强的松龙(R-CHOP)免疫化疗。由于乙型肝炎病毒血清学检测呈阳性,特别是抗乙型肝炎表面抗体、总抗乙型肝炎核心抗体和抗乙型肝炎e抗原抗体呈阳性,因此在治疗的同时使用拉米夫定进行抗病毒治疗,并使用双膦酸盐治疗以防止骨吸收。免疫化疗结束后,又辅以肩部放疗。经过三年多的缓解后,患者发生了缺血性中风,表现为右侧偏瘫。在接受物理治疗后,患者目前正在接受血栓性疾病的评估,由于经颅多普勒气泡试验呈阳性,高度怀疑存在卵圆孔未闭,因此还需要进一步的心脏评估。
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Primary Bone Lymphoma of the Scapula.

Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. The presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring fingers. The 45-year-old man underwent several radiological and neurological assessments of the palm, elbow, and neck before radiographs revealed a tumor of the left shoulder. Once diffuse large B-cell lymphoma was confirmed, immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and methylprednisolone (R-CHOP) started. The treatment was accompanied by antiviral treatment with lamivudine due to positive hepatitis B virus serology, specifically anti-HBs (hepatitis B surface) antibody, total anti-HBc (hepatitis B core) antibody, and anti-HBe (hepatitis B e antigen) antibody, together with bisphosphonate treatment for the prevention of bone resorption. Once immunochemotherapy was finished, the treatment was supplemented by radiotherapy of the shoulder. After more than three years of remission, the patient had an ischemic stroke manifesting with right-sided hemiparesis. Following physical therapy, the patient is currently in the process of evaluation for thrombophilia, as well as further cardiac assessment due to the positive transcranial Doppler bubble test, setting high suspicion for the presence of patent foramen ovale.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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