Niya Narayanan, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Haritha Sagili, Bobby Zachariah, Dukhabandhu Naik, Ayan Roy, Chandhana Merugu
{"title":"患有和未患有妊娠糖尿病的孕妇的胰岛素敏感性、胰岛细胞功能和内分泌轴。","authors":"Niya Narayanan, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Haritha Sagili, Bobby Zachariah, Dukhabandhu Naik, Ayan Roy, Chandhana Merugu","doi":"10.4103/ijem.ijem_7_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to compare insulin sensitivity, islet cell function, and incretin axes in pregnant subjects with GDM and normal healthy controls.</p><p><strong>Methods: </strong>Pregnant women at 24 to 28 weeks of gestation were subjected to a 75 g oral glucose tolerance test (OGTT). Samples for glucose, insulin, glucagon, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were collected at 0, 30, 60, and 120 min during the OGTT. The Matsuda index (MI) and insulin secretion and sensitivity index-2 (ISSI-2) were assessed. The glucagon suppression index (GSI) was calculated along with the area under the curve (AUC) for glucose, insulin, glucagon, GLP-1, and GIP.</p><p><strong>Results: </strong>A total of 48 pregnant women (25 GDM and 23 controls) were finally analysed. The MI and ISSI-2 were low in the GDM group [4.31 vs. 5.42; <i>P</i> = 0.04], [1.99 vs. 3.18, <i>P</i> ≤ 0.01] respectively). Total AUC<sub>glucagon</sub> was higher in the GDM group (7411.7 vs. 6320.1, <i>P</i> = 0.02). GSI<sub>30</sub> was significantly lower in the GDM group (-62.6 vs. -24.7, <i>P</i> = 0.03). Fasting GLP-1 levels were low in GDM women (17.3 vs. 22.2, <i>P</i> = 0.04). The total AUC<sub>GLP-1</sub> positively correlated with total GSI in the GDM group.</p><p><strong>Conclusion: </strong>Asian-Indian GDM women have high insulin insensitivity, islet cell dysfunction, and low fasting GLP-1. Incretin axis dysfunction plays a potential role in their islet cell dysfunction.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"28 1","pages":"71-79"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962776/pdf/","citationCount":"0","resultStr":"{\"title\":\"Insulin Sensitivity, Islet Cell Function, and Incretin Axis in Pregnant Women With and Without Gestational Diabetes Mellitus.\",\"authors\":\"Niya Narayanan, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Haritha Sagili, Bobby Zachariah, Dukhabandhu Naik, Ayan Roy, Chandhana Merugu\",\"doi\":\"10.4103/ijem.ijem_7_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The aim of this study was to compare insulin sensitivity, islet cell function, and incretin axes in pregnant subjects with GDM and normal healthy controls.</p><p><strong>Methods: </strong>Pregnant women at 24 to 28 weeks of gestation were subjected to a 75 g oral glucose tolerance test (OGTT). Samples for glucose, insulin, glucagon, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were collected at 0, 30, 60, and 120 min during the OGTT. The Matsuda index (MI) and insulin secretion and sensitivity index-2 (ISSI-2) were assessed. The glucagon suppression index (GSI) was calculated along with the area under the curve (AUC) for glucose, insulin, glucagon, GLP-1, and GIP.</p><p><strong>Results: </strong>A total of 48 pregnant women (25 GDM and 23 controls) were finally analysed. The MI and ISSI-2 were low in the GDM group [4.31 vs. 5.42; <i>P</i> = 0.04], [1.99 vs. 3.18, <i>P</i> ≤ 0.01] respectively). Total AUC<sub>glucagon</sub> was higher in the GDM group (7411.7 vs. 6320.1, <i>P</i> = 0.02). GSI<sub>30</sub> was significantly lower in the GDM group (-62.6 vs. -24.7, <i>P</i> = 0.03). Fasting GLP-1 levels were low in GDM women (17.3 vs. 22.2, <i>P</i> = 0.04). 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引用次数: 0
摘要
引言本研究旨在比较 GDM 孕妇和正常健康对照组的胰岛素敏感性、胰岛细胞功能和增量素轴:方法:对妊娠 24 至 28 周的孕妇进行 75 克口服葡萄糖耐量试验(OGTT)。在 OGTT 期间的 0、30、60 和 120 分钟采集葡萄糖、胰岛素、胰高血糖素、胰高血糖素样肽-1(GLP-1)和葡萄糖依赖性促胰岛素多肽(GIP)样本。评估了松田指数(MI)和胰岛素分泌与敏感性指数-2(ISSI-2)。计算胰高血糖素抑制指数(GSI)以及葡萄糖、胰岛素、胰高血糖素、GLP-1 和 GIP 的曲线下面积(AUC):最终对 48 名孕妇(25 名 GDM 孕妇和 23 名对照组孕妇)进行了分析。GDM组的MI和ISSI-2较低[分别为4.31 vs. 5.42; P = 0.04]和[分别为1.99 vs. 3.18, P ≤ 0.01])。GDM组的胰高血糖素总AUC较高(7411.7 vs. 6320.1,P = 0.02)。GDM组的GSI30明显降低(-62.6 vs. -24.7,P = 0.03)。GDM 妇女的空腹 GLP-1 水平较低(17.3 vs. 22.2,P = 0.04)。GDM组的总AUCGLP-1与总GSI呈正相关:结论:亚裔印度 GDM 妇女对胰岛素高度不敏感、胰岛细胞功能障碍、空腹 GLP-1 低。胰岛素轴功能障碍可能是导致胰岛细胞功能障碍的原因之一。
Insulin Sensitivity, Islet Cell Function, and Incretin Axis in Pregnant Women With and Without Gestational Diabetes Mellitus.
Introduction: The aim of this study was to compare insulin sensitivity, islet cell function, and incretin axes in pregnant subjects with GDM and normal healthy controls.
Methods: Pregnant women at 24 to 28 weeks of gestation were subjected to a 75 g oral glucose tolerance test (OGTT). Samples for glucose, insulin, glucagon, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were collected at 0, 30, 60, and 120 min during the OGTT. The Matsuda index (MI) and insulin secretion and sensitivity index-2 (ISSI-2) were assessed. The glucagon suppression index (GSI) was calculated along with the area under the curve (AUC) for glucose, insulin, glucagon, GLP-1, and GIP.
Results: A total of 48 pregnant women (25 GDM and 23 controls) were finally analysed. The MI and ISSI-2 were low in the GDM group [4.31 vs. 5.42; P = 0.04], [1.99 vs. 3.18, P ≤ 0.01] respectively). Total AUCglucagon was higher in the GDM group (7411.7 vs. 6320.1, P = 0.02). GSI30 was significantly lower in the GDM group (-62.6 vs. -24.7, P = 0.03). Fasting GLP-1 levels were low in GDM women (17.3 vs. 22.2, P = 0.04). The total AUCGLP-1 positively correlated with total GSI in the GDM group.
Conclusion: Asian-Indian GDM women have high insulin insensitivity, islet cell dysfunction, and low fasting GLP-1. Incretin axis dysfunction plays a potential role in their islet cell dysfunction.
期刊介绍:
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