Mitra Baghali, Hakimeh Ziyadi, Seeram Ramakrishna, Anna Chernova, Antonio Di Martino
{"title":"载入红霉素的明胶/甘油复合薄膜中甘油含量的影响","authors":"Mitra Baghali, Hakimeh Ziyadi, Seeram Ramakrishna, Anna Chernova, Antonio Di Martino","doi":"10.1134/s0965545x23600357","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Due to wide application of biomaterials in drug delivery systems for wound healing, this research work is focused on the development and characterization of a Gelatin/Glycerol composite film for delivering the antibiotic Erythromycin. The aim was preparing gelatin/glycerol films loaded with erythromycin suitable for a future application as a patch for skin wound healing application. A set of films were prepared with various gelatin to glycerol weight ratio and the impact of glycerol content on the mechanical, physicochemical and thermal behavior of film evaluated. Erythromycin was loaded into the film and the antibacterial activity evaluated versus <i>E.coli</i> and <i>S.aureus</i>. Results demonstrate a correlation between the content of glycerol and the physico-chemical properties of the film. The Ge/GY films containing the drug show good antibacterial effects only against <i>Staphylococcus aureus</i> bacteria. TGA and DSC of Ge/ GY thin films showed thermal stability until 110°C, however, the complete decomposition occurred at 350°C.</p>","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Glycerol Content in Gelatin/Glycerol Composite Films Loaded with Erythromycin\",\"authors\":\"Mitra Baghali, Hakimeh Ziyadi, Seeram Ramakrishna, Anna Chernova, Antonio Di Martino\",\"doi\":\"10.1134/s0965545x23600357\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>Due to wide application of biomaterials in drug delivery systems for wound healing, this research work is focused on the development and characterization of a Gelatin/Glycerol composite film for delivering the antibiotic Erythromycin. The aim was preparing gelatin/glycerol films loaded with erythromycin suitable for a future application as a patch for skin wound healing application. A set of films were prepared with various gelatin to glycerol weight ratio and the impact of glycerol content on the mechanical, physicochemical and thermal behavior of film evaluated. Erythromycin was loaded into the film and the antibacterial activity evaluated versus <i>E.coli</i> and <i>S.aureus</i>. Results demonstrate a correlation between the content of glycerol and the physico-chemical properties of the film. The Ge/GY films containing the drug show good antibacterial effects only against <i>Staphylococcus aureus</i> bacteria. TGA and DSC of Ge/ GY thin films showed thermal stability until 110°C, however, the complete decomposition occurred at 350°C.</p>\",\"PeriodicalId\":738,\"journal\":{\"name\":\"Polymer Science, Series A\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer Science, Series A\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1134/s0965545x23600357\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Science, Series A","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1134/s0965545x23600357","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Effect of Glycerol Content in Gelatin/Glycerol Composite Films Loaded with Erythromycin
Abstract
Due to wide application of biomaterials in drug delivery systems for wound healing, this research work is focused on the development and characterization of a Gelatin/Glycerol composite film for delivering the antibiotic Erythromycin. The aim was preparing gelatin/glycerol films loaded with erythromycin suitable for a future application as a patch for skin wound healing application. A set of films were prepared with various gelatin to glycerol weight ratio and the impact of glycerol content on the mechanical, physicochemical and thermal behavior of film evaluated. Erythromycin was loaded into the film and the antibacterial activity evaluated versus E.coli and S.aureus. Results demonstrate a correlation between the content of glycerol and the physico-chemical properties of the film. The Ge/GY films containing the drug show good antibacterial effects only against Staphylococcus aureus bacteria. TGA and DSC of Ge/ GY thin films showed thermal stability until 110°C, however, the complete decomposition occurred at 350°C.
期刊介绍：
Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.
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