Ana Gutierrez del Arroyo, Tom. E. F. Abbott, Akshaykumar Patel, Salma Begum, Priyanthi Dias, David Brealey, Rupert M. Pearse, Vikas Kapil, Gareth L. Ackland, the SPACE trial investigators
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Preoperative activation of the Renin–Angiotensin system and myocardial injury in noncardiac surgery: Post Hoc Analysis of the SPACE randomised controlled Trial
Background Hypertension therapy in older adults is often suboptimal, in part due to inadequate suppression of the renin-angiotensin-aldosterone system (RAAS). We hypothesised that distinct endotypes of RAAS activation before noncardiac surgery are associated with increased risk of myocardial injury.
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