含有抗菌剂的 PMMA 和 PVP 混合纳米纤维:光谱和质谱表征

Pub Date : 2024-03-26 DOI:10.1063/10.0024959
A. M. Plokhotnichenko, V. A. Karachevtsev, V. A. Pashynska, P. O. Kuzema
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引用次数: 0

摘要

电纺聚合物纳米纤维掺入了一些药物或生物活性纳米粒子,在伤口包扎、药物输送和组织工程等生物医学领域有着广泛的应用。将几种具有不同特性的聚合物混合在一起,可以获得具有更好的物理化学和机械特性的新材料,还可以控制医疗制剂(包括抗菌剂、抗真菌剂和其他物质)的加入和释放。在这项研究中,提出了一种新方法来制备两种聚合物(聚乙烯吡咯烷酮(PVP)和聚甲基丙烯酸甲酯(PMMA))的混合物,从而生产出生物相容性纳米纤维,并在其中加入抗菌剂--苯丙氨酸或纳米银粒子。获得的纳米纤维直径在 2-4 μm 之间。在水溶液中将抗菌剂加入 PVP,然后将制备的加合物干燥,并在有机溶剂中与 PMMA 混合。在这种纳米纤维毡中,PMMA 提供了毡的机械强度,并有助于抗菌剂的逐渐释放。通过光谱仪监测了含有抗菌剂的 PVP:PMMA 纳米纤维在不同阶段的形成情况。通过光谱和质谱分析,研究并确认了纳米纤维毡在润湿过程中抗菌剂的释放情况。
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PMMA and PVP blended nanofibers with incorporated antimicrobial agent: Spectroscopy and mass spectrometry characterization
Electrospun polymeric nanofibers incorporated with some medicines or biologically active nanoparticles have a huge range of various applications in biomedical fields such as wound dressing, drug delivery, and tissue engineering. Blending several polymers with different properties allows one to obtain a new material with improved physicochemical and mechanical characteristics, as well as to control the incorporation and release of medical agents, including antimicrobial, antifungal, and other substances. In this work, a novel approach to prepare a blend of two polymers [polyvinylpyrrolidone (PVP) and polymethyl methacrylate (PMMA)] to produce biocompatible nanofibers with incorporated antibacterial agents — phenylalanine or silver nanoparticles is proposed. The diameter of the obtained nanofibers is in the range of 2–4 μm. Antimicrobial agents are incorporated in PVP in an aqueous solution, then the prepared adduct is dried and mixed with PMMA in an organic solvent. In this nanofiber mat, PMMA provides the mechanical strength of the mat and assists in the gradual release of the antimicrobial agents. The formation of the PVP:PMMA nanofibers with incorporated antimicrobial agents at different stages was monitored by spectroscopy. The release of antimicrobial agents from the nanofibers mat during wetting was studied and confirmed by spectroscopy and mass spectrometry investigations.
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