促进心脏生长和再生的表观遗传决定因素和非心肌信号通路

IF 12 1区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-03-26 DOI:10.1016/j.pharmthera.2024.108638

Jihyun Jang , Federica Accornero , Deqiang Li

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引用次数: 0

摘要

先天性心脏病是全球最常见的出生缺陷。心肌发育缺陷是多种先天性心脏病的主要表现或相关因素。在心脏发育过程中，包括心内膜和心外膜在内的非心肌组织是心肌生长和成熟的支持枢纽。最近的研究结果表明，表观遗传学在非心肌细胞支持心肌发育方面发挥着新的作用。了解表观遗传因素如何调控非心肌组织的生长信号通路，将有可能发现先天性心脏病的新发病机制，并为心脏再生的新型治疗策略提供启示。

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Epigenetic determinants and non-myocardial signaling pathways contributing to heart growth and regeneration

Congenital heart disease is the most common birth defect worldwide. Defective cardiac myogenesis is either a major presentation or associated with many types of congenital heart disease. Non-myocardial tissues, including endocardium and epicardium, function as a supporting hub for myocardial growth and maturation during heart development. Recent research findings suggest an emerging role of epigenetics in nonmyocytes supporting myocardial development. Understanding how growth signaling pathways in non-myocardial tissues are regulated by epigenetic factors will likely identify new disease mechanisms for congenital heart diseases and shed lights for novel therapeutic strategies for heart regeneration.

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来源期刊

Pharmacology & Therapeutics 医学-药学

CiteScore

23.00

自引率

0.70%

发文量

222

审稿时长

90 days

期刊介绍： Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.