Parul Kamboj, Geeti Khullar, Sanjeev Handa, Arnab Pal, Uma Nahar Saikia, Dipankar De
{"title":"FoxO1 在痤疮中的作用以及异维A酸对 FoxO1 表达的影响。","authors":"Parul Kamboj, Geeti Khullar, Sanjeev Handa, Arnab Pal, Uma Nahar Saikia, Dipankar De","doi":"10.4103/idoj.idoj_455_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (<i>FoxO1</i>) and role of isotretinoin in improving acne via modulating this pathway.</p><p><strong>Aim: </strong>To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of <i>FoxO1</i>, peroxisome proliferator-activated receptor (<i>PPARγ</i>), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.</p><p><strong>Results: </strong>The gene expression of <i>FoxO1</i> was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in <i>FoxO1</i> expression in acne patients at mRNA (<i>P</i> = 0.05) level was observed. There was a significant decrease in grade 3 positivity of <i>FoxO1</i> at protein level (<i>P</i> = 0.0009). A decrease in androgen receptor positivity (<i>P</i> = 0.055) at protein level was also observed.</p><p><strong>Conclusion: </strong>Reduction in <i>FoxO1</i> expression appears to be an important mechanism of action of isotretinoin in acne.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"15 2","pages":"252-254"},"PeriodicalIF":1.9000,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969248/pdf/","citationCount":"0","resultStr":"{\"title\":\"Role of <i>FoxO1</i> in Acne and Effect of Isotretinoin on <i>FoxO1</i> Expression.\",\"authors\":\"Parul Kamboj, Geeti Khullar, Sanjeev Handa, Arnab Pal, Uma Nahar Saikia, Dipankar De\",\"doi\":\"10.4103/idoj.idoj_455_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (<i>FoxO1</i>) and role of isotretinoin in improving acne via modulating this pathway.</p><p><strong>Aim: </strong>To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of <i>FoxO1</i>, peroxisome proliferator-activated receptor (<i>PPARγ</i>), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.</p><p><strong>Results: </strong>The gene expression of <i>FoxO1</i> was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in <i>FoxO1</i> expression in acne patients at mRNA (<i>P</i> = 0.05) level was observed. There was a significant decrease in grade 3 positivity of <i>FoxO1</i> at protein level (<i>P</i> = 0.0009). A decrease in androgen receptor positivity (<i>P</i> = 0.055) at protein level was also observed.</p><p><strong>Conclusion: </strong>Reduction in <i>FoxO1</i> expression appears to be an important mechanism of action of isotretinoin in acne.</p>\",\"PeriodicalId\":13335,\"journal\":{\"name\":\"Indian Dermatology Online Journal\",\"volume\":\"15 2\",\"pages\":\"252-254\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969248/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Dermatology Online Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/idoj.idoj_455_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Dermatology Online Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/idoj.idoj_455_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Role of FoxO1 in Acne and Effect of Isotretinoin on FoxO1 Expression.
Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating this pathway.
Aim: To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of FoxO1, peroxisome proliferator-activated receptor (PPARγ), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.
Results: The gene expression of FoxO1 was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in FoxO1 expression in acne patients at mRNA (P = 0.05) level was observed. There was a significant decrease in grade 3 positivity of FoxO1 at protein level (P = 0.0009). A decrease in androgen receptor positivity (P = 0.055) at protein level was also observed.
Conclusion: Reduction in FoxO1 expression appears to be an important mechanism of action of isotretinoin in acne.
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