B. Wang, X. Y. Ma, W. Yao, S. Y. Wu, Y. Zhang, W. Liu, E. J. Gao
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引用次数: 0
摘要
摘要 以苯基丙二酸和膦为原料，在水热条件下设计并合成了一种新的锰(II)配合物。单晶 X 射线衍射是有效的表征方法。此外，还利用紫外光谱测定了复合物与 FS-DNA（鱼精 DNA）的相互作用以及 DNA 结合常数。结果表明，该复合物对癌细胞有明显的凋亡作用，因此对治疗癌症有重要意义。
Binding Studies of Novel Manganese Complexes to DNA
Abstract
A new Mn(II) complex was designed and synthesized in hydrothermal conditions using phenylmalonic acid and phosphine as raw materials. The effective characterization method was single-crystal X-ray diffraction. Besides, the interaction with FS-DNA (fish sperm DNA) and the DNA binding constants of the complex were determined by UV spectroscopy. The results showed that it was a significant apoptotic effect on cancer cells; therefore, the synthesized Mn(II) complex is important for the treatment of cancer.
期刊介绍：
Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.
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