探索外泌体与免疫肿瘤微环境之间的动态相互作用:对乳腺癌进展和治疗策略的影响。

IF 7.4 1区 医学 Q1 Medicine Breast Cancer Research Pub Date : 2024-03-29 DOI:10.1186/s13058-024-01810-z
Sahar Safaei, Manouchehr Fadaee, Omid Rahbar Farzam, Amirhossein Yari, Elham Poursaei, Cynthia Aslan, Sahar Samemaleki, Dariush Shanehbandi, Behzad Baradaran, Tohid Kazemi
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引用次数: 0

摘要

乳腺癌仍然是全球关注的一个重大健康问题,需要深入了解癌细胞与免疫系统之间复杂的相互作用。最近的研究表明,外泌体在促进细胞间交流方面具有重要功能,并参与了癌症的发展。肿瘤衍生的外泌体已被确定为乳腺癌的重要调节因子,在调节免疫细胞活性和促进病情发展方面发挥着至关重要的作用。本研究旨在探讨肿瘤衍生的外泌体对乳腺癌免疫细胞的多种影响。具体来说,我们将研究它们在影响免疫细胞极化、促进免疫逃避和改变肿瘤微环境方面的作用。此外,我们还将探索由免疫细胞产生的外泌体的新领域及其在预防乳腺癌中的潜在作用。本文重点关注强调免疫细胞产生的外泌体的免疫调节特性的新研究。本文还探讨了将这些外泌体作为早期识别和预防乳腺癌的治疗剂或生物标志物的可能性。对肿瘤和免疫细胞形成的外泌体之间相互联系的探索,以及对来自免疫细胞的外泌体日益重要的认识,为乳腺癌治疗和预防领域新方法的发展提供了一条潜在的途径。
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Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies.

Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex interaction between cancerous cells and the immune system. Recent studies have shown the significant function of exosomes in facilitating intercellular communication and their participation in the advancement of cancer. Tumor-derived exosomes have been identified as significant regulators in the context of breast cancer, playing a crucial role in modulating immune cell activity and contributing to the advancement of the illness. This study aims to investigate the many effects of tumor-derived exosomes on immune cells in the setting of breast cancer. Specifically, we will examine their role in influencing immune cell polarization, facilitating immunological evasion, and modifying the tumor microenvironment. Furthermore, we explore the nascent domain of exosomes produced from immune cells and their prospective involvement in the prevention of breast cancer. This paper focuses on new research that emphasizes the immunomodulatory characteristics of exosomes produced from immune cells. It also explores the possibility of these exosomes as therapeutic agents or biomarkers for the early identification and prevention of breast cancer. The exploration of the reciprocal connections between exosomes formed from tumors and immune cells, together with the rising significance of exosomes derived from immune cells, presents a potential avenue for the advancement of novel approaches in the field of breast cancer therapy and prevention.

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来源期刊
CiteScore
12.00
自引率
0.00%
发文量
76
审稿时长
12 weeks
期刊介绍: Breast Cancer Research, an international, peer-reviewed online journal, publishes original research, reviews, editorials, and reports. It features open-access research articles of exceptional interest across all areas of biology and medicine relevant to breast cancer. This includes normal mammary gland biology, with a special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal covers preclinical, translational, and clinical studies with a biological basis, including Phase I and Phase II trials.
期刊最新文献
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