近视儿童和青少年对近距离工作的脉络膜反应存在差异。

IF 5.4 3区 材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-04-02 DOI:10.1186/s40662-024-00382-5
Mengqi Liu, Yuanyuan Wang, Haoer Li, Yunpeng Zhao, Min Ma, Shihan Xu, Xiaohuan Wei, Ruiyan Xu, Ruikang Tian, Xiangtian Zhou, Hao Wu
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引用次数: 0

摘要

背景:近距离工作通常被认为是近视发生和发展的风险因素。本研究旨在调查儿童和青少年对短暂近距离工作的脉络膜反应:方法:30 名近视医学生(18-28 岁)和 30 名近视儿童(8-12 岁)参加了这项研究。方法:30 名近视医学生(18-28 岁)和 30 名近视儿童(8-12 岁)参加了这项研究。在距离 33 厘米处进行 20 分钟、40 分钟和 60 分钟的近距离工作之前和之后,分别用扫源光学相干断层成像/光学相干断层血管成像(SS-OCT/OCTA)测量了脉络膜下总面积(TCA)、管腔面积(LA)、基质面积(SA)、脉络膜血管指数(CVI)和绒毛膜血流缺损(CcFD)以及脉络膜下厚度(SFCT)。结果:在成人中,20 分钟的近距离工作导致 SFCT(- 5.1 ± 6.5 μm)、LA[(- 19.2 ± 18.6)×103 μm2]、SA[(- 8.2 ± 12.6)×103 μm2]和 TCA[(- 27.4 ± 24.9)×103 μm2](均为 P 3 μm2],同时伴有 CVI 下降(- 0.39% ± 0.70%)和 CcFD 增加(0.30% ± 0.78%)(均为 P 3 μm2],以及 TCA [(9.7 ± 25.3)×103 μm2]和 CVI 下降(- 0.28% ± 0.72%)(均为 P 结论:儿童和成人在近距离工作时脉络膜血管和绒毛膜灌注变化的时间特征和幅度并不相同。儿童脉络膜对近距离工作的最初反应出现在脉络膜瓣,而成人则出现在中型和大型血管:试验注册:临床试验注册中心(ChiCTR),ChiCTR2000040205。注册日期:2020 年 11 月 25 日,https://www.chictr.org.cn/bin/project/edit?pid=64501 。
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Differences in choroidal responses to near work between myopic children and young adults.

Background: Near work is generally considered as a risk factor for myopia onset and progression. This study aimed to investigate the choroidal responses to a brief-period of near work in children and young adults.

Methods: Thirty myopic medical students (aged 18-28 years) and 30 myopic children (aged 8-12 years) participated in this study. The submacular total choroidal area (TCA), luminal area (LA), stromal area (SA), choroidal vascularity index (CVI) and choriocapillaris flow deficit (CcFD), as well as subfoveal choroidal thickness (SFCT) were measured with swept-source optical coherence tomography/optical coherence tomography angiography (SS-OCT/OCTA) before and immediately after 20 min, 40 min, 60 min of near work at a distance of 33 cm.

Results: In adults, 20 min of near work induced a significant reduction in SFCT (- 5.1 ± 6.5 μm), LA [(- 19.2 ± 18.6) × 103 μm2], SA [(- 8.2 ± 12.6) × 103 μm2] and TCA [(- 27.4 ± 24.9) × 103 μm2] (all P < 0.01). After 40 min of near work, LA was still reduced [(- 9.4 ± 18.3) × 103 μm2], accompanied with a decreased CVI (- 0.39% ± 0.70%) and an increased CcFD (0.30% ± 0.78%) (all P < 0.05). After 60 min of near work, CVI was still reduced (- 0.28% ± 0.59%), and CcFD was still increased (0.37% ± 0.75%) (all P < 0.05). In children, 20 min of near work induced a significant increase in CcFD (0.55% ± 0.64%), while 60 min of near work induced increases in SA [(7.2 ± 13.0) × 103 μm2] and TCA [(9.7 ± 25.3) × 103 μm2] and a reduction in CVI (- 0.28% ± 0.72%) (all P < 0.05). Children exhibited lower near work-induced LA and TCA reduction than adults, with a mean difference of - 0.86% and - 0.82%, respectively (all P < 0.05).

Conclusions: The temporal characteristics and magnitude of changes of choroidal vascularity and choriocapillaris perfusion during near work was not identical between children and adults. The initial response to near work was observed in choriocapillaris in children, whereas it was observed in the medium- and large-sized vessels in adults.

Trial registration: Clinical Trial Registry (ChiCTR), ChiCTR2000040205. Registered on 25 November 2020, https://www.chictr.org.cn/bin/project/edit?pid=64501 .

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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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