Hongbo Zeng, Ziyi Liu, Yunhui He, Huixiang Chen, Jun He, Mingke Liu, Shuiqing Wu, Haiqing He, Changkun Huang, Ran Xu
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We used logistic regression models and restrictive cubic spline curves to explore the influence of vitamins.</p><p><strong>Results: </strong>The regression model exposed that compared to lower intake, high intake of vitamin B6 [Q4: OR (95% CI) = 0.76 (0.62, 0.93)], vitamin C [Q4: OR (95% CI) = 0.73 (0.59, 0.90)] and vitamin D [Q4: OR (95% CI) = 0.77 (0.64, 0.94)] individually exerted protective effects against the prevalence of kidney stones. Furthermore, the restrictive cubic spline analysis showed that the protective effect against the prevalence of kidney stones is enhanced as the take of vitamin B6 and vitamin D increased. Moreover, with the increase in vitamin C intake, its protective effect may turn into a risk factor. Regarding mixed exposure, Cluster 4 exhibited a significant protective effect against kidney stones compared with Cluster 1 [Model 3: OR (95% CI) = 0.79 (0.64, 0.98)].</p><p><strong>Conclusions: </strong>Our research revealed that high levels of vitamin B6 and vitamin D intake were linked to a lower prevalence of kidney stone. With the gradual increase intake of vitamin C, the prevalence of kidney calculi decreased first and then increased. 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引用次数: 0
摘要
研究背景本研究旨在探讨常见单种维生素和维生素组合摄入量的变化与肾结石发病率之间的关系:我们利用美国国家健康调查(NHANES)的数据,研究了九种常见维生素与肾结石患病率之间的关系。我们采用无监督 K-means 聚类方法将参与者分为几种维生素摄入模式。我们使用逻辑回归模型和限制性三次样条曲线来探讨维生素的影响:回归模型显示,与低摄入量相比,高摄入量的维生素 B6 [Q4: OR (95% CI) = 0.76 (0.62, 0.93)]、维生素 C [Q4: OR (95% CI) = 0.73 (0.59, 0.90)]和维生素 D [Q4: OR (95% CI) = 0.77 (0.64, 0.94)]对肾结石的发病率具有保护作用。此外,限制性立方样条分析表明,随着维生素 B6 和维生素 D 摄入量的增加,对肾结石患病率的保护作用也会增强。此外,随着维生素 C 摄入量的增加,其保护作用可能会转化为风险因素。在混合暴露方面,与群组 1 相比,群组 4 对肾结石具有显著的保护作用[模型 3:OR(95% CI)= 0.79 (0.64, 0.98)]:我们的研究表明,维生素 B6 和维生素 D 摄入量高与肾结石发病率低有关。随着维生素 C 摄入量的逐渐增加,肾结石的发病率先下降后上升。此外,同时摄入九种维生素是肾结石的保护因素。
Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.
Background: This research aimed to explore the association between changes in the intake of common individual vitamins and combinations of vitamins and the prevalence of kidney calculi.
Methods: We used data from NHANES to investigate the association between nine common vitamins and kidney stone prevalence. Participants were clustered into several vitamin exposure patterns using an unsupervised K-means clustering method. We used logistic regression models and restrictive cubic spline curves to explore the influence of vitamins.
Results: The regression model exposed that compared to lower intake, high intake of vitamin B6 [Q4: OR (95% CI) = 0.76 (0.62, 0.93)], vitamin C [Q4: OR (95% CI) = 0.73 (0.59, 0.90)] and vitamin D [Q4: OR (95% CI) = 0.77 (0.64, 0.94)] individually exerted protective effects against the prevalence of kidney stones. Furthermore, the restrictive cubic spline analysis showed that the protective effect against the prevalence of kidney stones is enhanced as the take of vitamin B6 and vitamin D increased. Moreover, with the increase in vitamin C intake, its protective effect may turn into a risk factor. Regarding mixed exposure, Cluster 4 exhibited a significant protective effect against kidney stones compared with Cluster 1 [Model 3: OR (95% CI) = 0.79 (0.64, 0.98)].
Conclusions: Our research revealed that high levels of vitamin B6 and vitamin D intake were linked to a lower prevalence of kidney stone. With the gradual increase intake of vitamin C, the prevalence of kidney calculi decreased first and then increased. In addition, the co-exposure of nine vitamins is a protective factor for kidney stone disease.
期刊介绍:
International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.