动态环境中上皮屏障功能的损伤控制

IF 4.5 3区 生物学 Q2 CELL BIOLOGY European journal of cell biology Pub Date : 2024-04-03 DOI:10.1016/j.ejcb.2024.151410
Tomohito Higashi, Akira C. Saito, Hideki Chiba
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引用次数: 0

摘要

上皮组织覆盖着多细胞动物内脏器官的表面和管腔,通过划分体内不同的区室,对体内环境的平衡起着至关重要的作用。这一重要作用被称为上皮屏障功能。上皮细胞像鹅卵石一样排列,错综复杂地结合在一起,形成上皮薄片,以维护这种屏障功能。限制溶质和液体通过细胞间隙扩散的核心是闭塞连接,脊椎动物的紧密连接和无脊椎动物的隔膜连接。作为上皮组织的一部分,细胞不断更新,老细胞被新细胞取代。与此同时,上皮组织作为一个整体会发生相对的重新排列、拉长和方向性移动。上皮薄片内部的运动或形状变化要求闭塞连接点发生重大变形和重新连接。最近的研究进展揭示了上皮细胞在动态环境中维持屏障功能的复杂机制。本综述旨在介绍这些值得关注的发现,并讨论一些尚未解答的问题。
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Damage control of epithelial barrier function in dynamic environments

Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital role is known as epithelial barrier function. Epithelial cells are arranged like cobblestones and intricately bind together to form an epithelial sheet that upholds this barrier function. Central to the restriction of solute and fluid diffusion through intercellular spaces are occluding junctions, tight junctions in vertebrates and septate junctions in invertebrates. As part of epithelial tissues, cells undergo constant renewal, with older cells being replaced by new ones. Simultaneously, the epithelial tissue undergoes relative rearrangement, elongating, and shifting directionally as a whole. The movement or shape changes within the epithelial sheet necessitate significant deformation and reconnection of occluding junctions. Recent advancements have shed light on the intricate mechanisms through which epithelial cells sustain their barrier function in dynamic environments. This review aims to introduce these noteworthy findings and discuss some of the questions that remain unanswered.

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来源期刊
European journal of cell biology
European journal of cell biology 生物-细胞生物学
CiteScore
7.30
自引率
1.50%
发文量
80
审稿时长
38 days
期刊介绍: The European Journal of Cell Biology, a journal of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and developmental biology are encouraged. Manuscripts describing significant technical advances are also welcome. In addition, papers dealing with biomedical issues of general interest to cell biologists will be published. Contributions addressing cell biological problems in prokaryotes and plants are also welcome.
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