CHK1 在癌症治疗中的功能和抑制剂

Q2 Medicine Medicine in Drug Discovery Pub Date : 2024-03-28 DOI:10.1016/j.medidd.2024.100185

Kailong Jiang , Minjie Deng , Wenjing Du , Tao Liu , Jia Li , Yubo Zhou

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引用次数: 0

摘要

CHK1 在癌症生物学中起着至关重要的作用，因为它能调节细胞周期检查点的激活和 DNA 修复。此外，人们还逐渐发现了 CHK1 的其他一些细胞功能。基于这些生物学功能，CHK1 已被视为癌症治疗的潜在靶点，但遗憾的是，迄今为止还没有 CHK1 抑制剂上市。有效生物标志物或联合用药有望推动 CHK1 抑制剂的开发进程。本文回顾了有关 CHK1 功能和抑制剂的最新研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Functions and inhibitors of CHK1 in cancer therapy

CHK1 plays a crucial role in cancer biology as it modulates cell cycle checkpoint activation and DNA repair. Furthermore, a number of other cellular functions of CHK1 are also gradually discovered. Based on these biological functions, CHK1 has been regarded as a potential target for cancer therapy, but regrettably no CHK1 inhibitors have been marketed up to now. The incorporation of effective biomarkers or combined combinations is expected to promote the development process of CHK1 inhibitors. This paper reviews the latest research progress on the functions and inhibitors of CHK1.

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