{"title":"用于抑制宫颈癌细胞的绿色合成钼纳米粒子的光催化降解和抗癌活性","authors":"Sandhya Kutikanti, S. Belwal","doi":"10.14233/ajchem.2024.30273","DOIUrl":null,"url":null,"abstract":"This work reports the synthesis of molybdenum nanoparticles (Mo NPs) through green routes using horse gram seed extracts and characterized by GC-MS, electronic (UV-visible) spectroscopy, IR, XRD and SEM techniques. Their potent applications as in vitro anticancer agent against HeLa cell lines and photocatalytic degradation of methyl orange (MO) and methyl violet (MV) dyes were also evaluated. The anti-malignant properties of Schiff base ligands [2-fluorobenzaldehyde semicarbazone (L1H) and 2-fluorobenzaldehyde thiosemicarbazone (L2H) with molybdenum metal precursor [dioxobis(2,4-pentanedionato)molybdenum] were also explored and their Mo complexes after conversion into nano form as both ligands, L1H and L2H approve their binding property based on molecular docking studies.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"12 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photocatalytic Degradation and Anticancer Activity of Green Synthesized Molybdenum Nanoparticles for Inhibiting the Cervical Cancer Cells\",\"authors\":\"Sandhya Kutikanti, S. Belwal\",\"doi\":\"10.14233/ajchem.2024.30273\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This work reports the synthesis of molybdenum nanoparticles (Mo NPs) through green routes using horse gram seed extracts and characterized by GC-MS, electronic (UV-visible) spectroscopy, IR, XRD and SEM techniques. Their potent applications as in vitro anticancer agent against HeLa cell lines and photocatalytic degradation of methyl orange (MO) and methyl violet (MV) dyes were also evaluated. The anti-malignant properties of Schiff base ligands [2-fluorobenzaldehyde semicarbazone (L1H) and 2-fluorobenzaldehyde thiosemicarbazone (L2H) with molybdenum metal precursor [dioxobis(2,4-pentanedionato)molybdenum] were also explored and their Mo complexes after conversion into nano form as both ligands, L1H and L2H approve their binding property based on molecular docking studies.\",\"PeriodicalId\":8494,\"journal\":{\"name\":\"Asian Journal of Chemistry\",\"volume\":\"12 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14233/ajchem.2024.30273\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14233/ajchem.2024.30273","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
摘要
本研究报告利用马齿苋种子提取物通过绿色方法合成了钼纳米粒子(Mo NPs),并通过气相色谱-质谱、电子(紫外-可见)光谱、红外光谱、X 射线衍射和扫描电镜技术对其进行了表征。此外,还评估了这些纳米粒子作为体外抗癌剂对 HeLa 细胞系的作用,以及对甲基橙(MO)和甲基紫(MV)染料的光催化降解作用。此外,还探讨了希夫碱配体[2-氟苯甲醛缩氨基脲(L1H)和 2-氟苯甲醛硫代缩氨基脲(L2H)]与钼金属前体[二氧双(2,4-戊二酮酸)钼]的抗恶性肿瘤特性,并根据分子对接研究验证了它们的钼配合物在转化为纳米形式后与配体 L1H 和 L2H 的结合特性。
Photocatalytic Degradation and Anticancer Activity of Green Synthesized Molybdenum Nanoparticles for Inhibiting the Cervical Cancer Cells
This work reports the synthesis of molybdenum nanoparticles (Mo NPs) through green routes using horse gram seed extracts and characterized by GC-MS, electronic (UV-visible) spectroscopy, IR, XRD and SEM techniques. Their potent applications as in vitro anticancer agent against HeLa cell lines and photocatalytic degradation of methyl orange (MO) and methyl violet (MV) dyes were also evaluated. The anti-malignant properties of Schiff base ligands [2-fluorobenzaldehyde semicarbazone (L1H) and 2-fluorobenzaldehyde thiosemicarbazone (L2H) with molybdenum metal precursor [dioxobis(2,4-pentanedionato)molybdenum] were also explored and their Mo complexes after conversion into nano form as both ligands, L1H and L2H approve their binding property based on molecular docking studies.