Jun Su Lee, Bumhee Yang, Hye Soon Shin, Heajung Lee, Hyun Gyung Chai, Hayoung Choi, Joung-Ho Han, Jai Hoon Yoon, Eung-Gook Kim, Hyun Lee
{"title":"炎症性肠病患者支气管扩张风险增加及相关风险因素:一项为期 10 年的韩国全国队列研究","authors":"Jun Su Lee, Bumhee Yang, Hye Soon Shin, Heajung Lee, Hyun Gyung Chai, Hayoung Choi, Joung-Ho Han, Jai Hoon Yoon, Eung-Gook Kim, Hyun Lee","doi":"10.1183/23120541.00087-2024","DOIUrl":null,"url":null,"abstract":"The association between inflammatory bowel disease (IBD) and an increased risk of bronchiectasis, as well as contributing factors, remains unclear. Additionally, whether bronchiectasis increases disease burden in IBD remains unknown. Therefore, this study aimed to 1) assess whether IBD increases the risk of incident bronchiectasis; 2) compare the risk of bronchiectasis between individuals with Crohn's disease (CD) and those with ulcerative colitis (UC); 3) identify risk factors for bronchiectasis in individuals with IBD; and 4) examine the disease burden in individuals with IBD and bronchiectasisversusthose without.We conducted a population-based matched cohort study involving adults aged ≥20 years with IBD, using data acquired from the National Health Insurance Service-National Sample Cohort database in Korea between 2002 and 2012.During the mean follow-up of 9.6 years, the incidence rate of bronchiectasis was 419.63/100 000 and 309.65/100 000 person-years (PY) in the IBD and matched cohorts (adjusted hazard ratio [aHR]=1.21, 95% confidence interval [CI]=1.05–1.39), respectively. UC was associated with increased bronchiectasis risk (aHR=1.42, 95% CI=1.19–1.69), while CD was not. Multivariate Cox regression analyses showed that age, male sex, medical aid, underweight status, chronic obstructive pulmonary disease, and diabetes mellitus were associated with an increased risk of bronchiectasis in the IBD cohort (p<0.05). The mortality, emergency department visit, and hospitalisation rates were significantly higher for individuals with IBD and bronchiectasis compared to those without bronchiectasis (p<0.05).IBD is associated with increased risk of bronchiectasis, which results in a greater disease burden in individuals with IBD.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: A 10-year Korean national cohort study\",\"authors\":\"Jun Su Lee, Bumhee Yang, Hye Soon Shin, Heajung Lee, Hyun Gyung Chai, Hayoung Choi, Joung-Ho Han, Jai Hoon Yoon, Eung-Gook Kim, Hyun Lee\",\"doi\":\"10.1183/23120541.00087-2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The association between inflammatory bowel disease (IBD) and an increased risk of bronchiectasis, as well as contributing factors, remains unclear. Additionally, whether bronchiectasis increases disease burden in IBD remains unknown. Therefore, this study aimed to 1) assess whether IBD increases the risk of incident bronchiectasis; 2) compare the risk of bronchiectasis between individuals with Crohn's disease (CD) and those with ulcerative colitis (UC); 3) identify risk factors for bronchiectasis in individuals with IBD; and 4) examine the disease burden in individuals with IBD and bronchiectasisversusthose without.We conducted a population-based matched cohort study involving adults aged ≥20 years with IBD, using data acquired from the National Health Insurance Service-National Sample Cohort database in Korea between 2002 and 2012.During the mean follow-up of 9.6 years, the incidence rate of bronchiectasis was 419.63/100 000 and 309.65/100 000 person-years (PY) in the IBD and matched cohorts (adjusted hazard ratio [aHR]=1.21, 95% confidence interval [CI]=1.05–1.39), respectively. UC was associated with increased bronchiectasis risk (aHR=1.42, 95% CI=1.19–1.69), while CD was not. Multivariate Cox regression analyses showed that age, male sex, medical aid, underweight status, chronic obstructive pulmonary disease, and diabetes mellitus were associated with an increased risk of bronchiectasis in the IBD cohort (p<0.05). The mortality, emergency department visit, and hospitalisation rates were significantly higher for individuals with IBD and bronchiectasis compared to those without bronchiectasis (p<0.05).IBD is associated with increased risk of bronchiectasis, which results in a greater disease burden in individuals with IBD.\",\"PeriodicalId\":11739,\"journal\":{\"name\":\"ERJ Open Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ERJ Open Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1183/23120541.00087-2024\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ERJ Open Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/23120541.00087-2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: A 10-year Korean national cohort study
The association between inflammatory bowel disease (IBD) and an increased risk of bronchiectasis, as well as contributing factors, remains unclear. Additionally, whether bronchiectasis increases disease burden in IBD remains unknown. Therefore, this study aimed to 1) assess whether IBD increases the risk of incident bronchiectasis; 2) compare the risk of bronchiectasis between individuals with Crohn's disease (CD) and those with ulcerative colitis (UC); 3) identify risk factors for bronchiectasis in individuals with IBD; and 4) examine the disease burden in individuals with IBD and bronchiectasisversusthose without.We conducted a population-based matched cohort study involving adults aged ≥20 years with IBD, using data acquired from the National Health Insurance Service-National Sample Cohort database in Korea between 2002 and 2012.During the mean follow-up of 9.6 years, the incidence rate of bronchiectasis was 419.63/100 000 and 309.65/100 000 person-years (PY) in the IBD and matched cohorts (adjusted hazard ratio [aHR]=1.21, 95% confidence interval [CI]=1.05–1.39), respectively. UC was associated with increased bronchiectasis risk (aHR=1.42, 95% CI=1.19–1.69), while CD was not. Multivariate Cox regression analyses showed that age, male sex, medical aid, underweight status, chronic obstructive pulmonary disease, and diabetes mellitus were associated with an increased risk of bronchiectasis in the IBD cohort (p<0.05). The mortality, emergency department visit, and hospitalisation rates were significantly higher for individuals with IBD and bronchiectasis compared to those without bronchiectasis (p<0.05).IBD is associated with increased risk of bronchiectasis, which results in a greater disease burden in individuals with IBD.
期刊介绍:
ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.