肺活量保留率受损时的内分泌和炎症标志物分析

Fabíola Ramos Jesus, Anna Clara Santiago Moraes, Ingrid Lorena Neves da Silva, Fabine Correia Passos, Cristina Salles, M. Neves, Gyselle Chrystina Baccan
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引用次数: 0

摘要

慢性阻塞性肺病(COPD)是一种以慢性气流阻塞为特征的肺部疾病。肺活量保留比值受损(PRISm)的人可能有罹患慢性阻塞性肺病的风险。本研究旨在从免疫反应和内分泌特征方面描述 PRISm 和慢性阻塞性肺病患者,以确定肺功能以外的差异。参与者进行了临床评估、肺功能测试和采血,以确定血清激素水平和细胞因子浓度。在营养状况、肺功能和合并症方面观察到了差异。PRISm组和COPD组的IL-6、IL-8、IL-10、IL-12和TNF水平没有差异。PRISm 和 COPD 患者的脱氢表雄酮(DHEA)和硫酸脱氢表雄酮(DHEA-S)水平均低于对照组。对 PRISm 和慢性阻塞性肺病患者进行的相关分析表明,血清中的 DHEA-S 和 DHEA 水平与 1 秒用力呼气容积 (FEV1) 和用力肺活量 (FVC) 呈正相关,而与 IL-8 水平呈负相关。结果表明,尽管肺功能参数存在差异,但 PRISm 组和 COPD 组在内分泌特征改变方面表现出相似性。这项研究首次尝试将 PRISm 患者的内分泌、免疫标记物和肺功能联系起来。
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Analysis of Endocrine and Inflammatory Markers in Preserved Ratio Impaired Spirometry
Chronic Obstructive Pulmonary Disease (COPD) is a disease of the lungs characterized by chronic airflow obstruction. Individuals with preserved ratio impaired spirometry (PRISm) may be at risk for developing COPD. This study aimed to characterize PRISm and COPD patients in terms of their immune response and endocrine profile to identify differences extending beyond lung function. The participants performed the clinical assessment, pulmonary function test, and blood collection to determine serum hormone levels and concentrations of cytokine. Differences were observed in the nutritional status, lung function, and comorbidity. There were no differences in IL-6, IL-8, IL-10, IL-12, and TNF levels between PRISm and COPD groups. Both PRISm and COPD patients have lower dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels than controls. Correlation analysis of PRISm and COPD patients revealed positive correlations between serum levels of DHEA-S and DHEA, with forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), which negatively correlated with IL-8 levels. The results indicated that despite differences in lung function parameters, the PRISm and COPD groups exhibited similarities in endocrine profile alterations. This study represents the first attempt to link endocrine with immune markers and lung function in individuals with PRISm.
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