Hosamadin Assadi, Nicholas Sawh, Ciara Bailey, Gareth Matthews, Rui Li, C. Grafton-Clarke, Z. Mehmood, Bahman Kasmai, Peter Swoboda, Andrew J Swift, R. J. V. D. Geest, Pankaj Garg
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引用次数: 0
摘要
背景:左心房(LA)评估是心血管不良后果的重要标志。心血管磁共振(CMR)可根据双平面长轴成像准确量化 LA 的容积和功能。我们的目的是将单平面得出的 LA 指数与双平面方法进行对比验证,以简化 cine CMR 的后处理。方法:本研究以利兹教学医院的 100 名患者为推导队列。对单平面方法进行了偏差校正,随后在 79 名受试者中进行了验证。结果:双平面方法与单平面方法之间存在显著差异:双平面和单平面的平均 LA 最大和最小容积以及 LA 射血分数(EF)之间存在明显差异(均 p <0.01)。在校正验证队列中的偏差后,观察到所有 LA 指数均有显著相关性(0.89 至 0.98)。单平面预测 LA 最大容积≥ 112 mL 的双平面临界值的曲线下面积(AUC)为 0.97,LA 最小容积≥ 44 mL 的曲线下面积(AUC)为 0.99,LA 搏出量(SV)≤ 21 mL 的曲线下面积(AUC)为 1,LA EF≤ 46% 的曲线下面积(AUC)为 1,(所有 p 均<0.001)。结论:单平面法与双平面法相比,LA容积和功能评估存在系统性偏差。校正偏差后,单平面 LA 容量和功能与双平面法相当。
Validation of Left Atrial Volume Correction for Single Plane Method on Four-Chamber Cine Cardiac MRI
Background: Left atrial (LA) assessment is an important marker of adverse cardiovascular outcomes. Cardiovascular magnetic resonance (CMR) accurately quantifies LA volume and function based on biplane long-axis imaging. We aimed to validate single-plane-derived LA indices against the biplane method to simplify the post-processing of cine CMR. Methods: In this study, 100 patients from Leeds Teaching Hospitals were used as the derivation cohort. Bias correction for the single plane method was applied and subsequently validated in 79 subjects. Results: There were significant differences between the biplane and single plane mean LA maximum and minimum volumes and LA ejection fraction (EF) (all p < 0.01). After correcting for biases in the validation cohort, significant correlations in all LA indices were observed (0.89 to 0.98). The area under the curve (AUC) for the single plane to predict biplane cutoffs of LA maximum volume ≥ 112 mL was 0.97, LA minimum volume ≥ 44 mL was 0.99, LA stroke volume (SV) ≤ 21 mL was 1, and LA EF ≤ 46% was 1, (all p < 0.001). Conclusions: LA volumetric and functional assessment by the single plane method has a systematic bias compared to the biplane method. After bias correction, single plane LA volume and function are comparable to the biplane method.
TomographyMedicine-Radiology, Nuclear Medicine and Imaging
CiteScore
2.70
自引率
10.50%
发文量
222
期刊介绍:
TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine.
Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians.
Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.