Probiotics. Review of the current state of the problem from the standpoint of clinical pharmacology and evidence-based medicine

When using antibiotics in the treatment of various diseases, the quantitative and qualitative composition of the microbiota, both pathogenic and symbiotic, changes dramatically. Both oral and parenteral use of antibacterial drugs has an impact and changes the quantitative and qualitative composition of the intestinal microbiota, which subsequently entails changes in the pathways of cell development and long-term violations of physiology at all levels of functioning of the macroorganism. In this article, the analysis of available data on modern probiotic drugs drugs that contribute to improving the normal microbiota of the human body was carried out. The undoubted effectiveness of various probiotics in acute and antibiotic-associated diarrhea, eradication of Helicobacter pylori was noted.