评估黄芩叶乙醇提取物对链脲佐菌素诱导的 Wistar 大鼠糖尿病的抗糖尿病活性

K. Sumathi, V. Priyanka, N. Kumar
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摘要

糖尿病是一种以血糖水平升高为特征的慢性代谢性疾病,影响着全球数百万人。本研究旨在评估黄芩叶乙醇提取物在链脲佐菌素(STZ)诱导的糖尿病 Wistar 大鼠模型中的潜在抗糖尿病活性。用 STZ 诱导 Wistar 大鼠患糖尿病,然后用黄芩叶乙醇提取物治疗。对空腹血糖水平、血清胰岛素水平、血脂状况和抗氧化酶活性等各种生化指标进行了评估。此外,还对胰腺组织进行了组织病理学检查,以评估萃取物对结构改变的影响。结果表明,与未治疗的糖尿病组相比,用星叶芹提取物治疗的大鼠空腹血糖水平明显降低。此外,该提取物还对血清胰岛素水平、血脂状况和抗氧化酶活性产生了积极影响,表明其具有改善糖尿病引起的代谢失调的潜力。胰腺组织的组织病理学分析表明,提取物处理组的胰岛结构得到了保护,这凸显了黄芩对 STZ 诱导的胰腺损伤的保护作用。
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Assessment Of The Anti-Diabetic Activicty Of Schefflera Stellata Leaves Ethanolic Extract On Streptozotocin-Induced Diabetes In Wistar Rats
Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, affecting millions of people worldwide. This study aimed to evaluate the potential anti-diabetic activity of Schefflera stellata leaves ethanolic extract in a streptozotocin (STZ)-induced diabetic Wistar rat model. Wistar rats were induced with diabetes using STZ and subsequently treated with Schefflera stellata leaves ethanolic extract. Various biochemical parameters such as fasting blood glucose levels, serum insulin levels, lipid profile, and antioxidant enzyme activities were assessed. Additionally, histopathological examination of pancreatic tissues was performed to evaluate the impact of the extract on structural alterations. The results revealed a significant reduction in fasting blood glucose levels in rats treated with Schefflera stellata extract compared to the untreated diabetic group. Moreover, the extract exhibited a positive influence on serum insulin levels, lipid profile, and antioxidant enzyme activities, suggesting its potential in ameliorating diabetes-induced metabolic dysregulation. Histopathological analysis of pancreatic tissues indicated a preservation of islet architecture in the extract-treated group, highlighting the protective effects of Schefflera stellata against STZ-induced pancreatic damage.
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