伊拉克血液透析慢性肾衰竭患者体内 STIM1 和 ORAI1 基因多态性对促红细胞生成素抵抗的影响

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Journal of Contemporary Medical Sciences Pub Date : 2024-02-26 DOI:10.22317/jcms.v10i1.1495
Farah f. Alsabbagh, Amal Umran Mosa, Abo Almaali, Hasanain Salah Jafer
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引用次数: 0

摘要

研究目的本研究旨在探讨慢性肾功能衰竭(CRF)患者体内储存操作钙通道(SOCs)信号转导的遗传多态性与促红细胞生成素治疗耐受性之间的相关性。贫血是慢性肾功能衰竭的一个重要并发症,了解导致耐药性的遗传因素可以深入了解影响治疗结果的潜在机制。具体来说,研究重点是探索促红细胞生成素激活的途径 SOC 与抗药性之间的关系,以应对 CRF 患者贫血带来的挑战。研究方法本研究选择了 STIM1 和 ORAI1 基因中的单核苷酸多态性。使用等位基因特异性聚合酶链反应技术进行基因分型,并通过社会科学统计软件包对数据进行分析。112 名接受血液透析的 CRF 患者中,58.9% 为男性,平均年龄(50.94±13.42)岁。结果我们发现,ORAI1 基因的 CC 基因型血红蛋白水平较高,STIM1 基因的 AA 基因型 EPO 水平较高,这两个基因的交互作用显示,CCGG 组血红蛋白水平较高,被认为是良好反应者,但只占患者的 4.5%:总之,SOCs 基因 ORAI1 和 STIM1 的基因多态性对伊拉克血液透析 CRF 患者的促红细胞生成素耐受性没有显著影响。
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The Impact of Genetic Polymorphisms in (STIM1 and ORAI1) on Erythropoietin Resistance in Patients with Chronic Renal Failure on Hemodialysis in Iraq
Objective: This study aims to investigate the correlation between genetic polymorphisms in store-operated calcium channels (SOCs) signaling and resistance to erythropoietin treatment in patients with chronic renal failure (CRF). Anemia is a significant complication of CRF, and understanding the genetic factors contributing to resistance could provide insights into potential mechanisms influencing treatment outcomes. Specifically, the focus is on exploring the relationship between SOCs, a pathway activated by erythropoietin, and resistance to address the challenges associated with anemia in CRF patients. Methods: In this study, a single nucleotide polymorphism in each STIM1 and ORAI1 gene was selected. Genotyping was done by using allele specific polymerase chain reaction technique and the data was analyzed through the Statistical Package for the Social Sciences. 112 patients with CRF on hemodialysis were enrolled 58.9% of them were men and the mean age was 50.94±13.42. Results: We found that CC genotype of ORAI1 gene has a higher hemoglobin level, AA genotype of STIM1 has a higher EPO level, the interaction of the two genes showed that CCGG group has a higher Hb level and is considered good responder but represents only 4.5% of the patients Conclusion: After all the genetic polymorphisms of SOCs genes ORAI1 and STIM1 have no significant impact on erythropoietin resistance in patients with CRF on hemodialysis in Iraq.
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来源期刊
Journal of Contemporary Medical Sciences
Journal of Contemporary Medical Sciences MEDICINE, GENERAL & INTERNAL-
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65
审稿时长
12 weeks
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