{"title":"中性粒细胞活化标志物 CD15+ 是 2 型糖尿病患者眼表损伤的预后因素之一","authors":"T. Zhmud, G. Drozhzhyna, L. Velychko","doi":"10.31288/oftalmolzh202411519","DOIUrl":null,"url":null,"abstract":"Purpose: To evaluate the prognostic value of the neutrophil activation marker CD15+ in ocular surface damage in type 2 diabetics. Material and Methods: This study was conducted from January 2021 to January 2021 at the Pirogov Vinnytsia Regional Clinical Hospital, the clinical site of the Medical University. A total of 60 type 2 diabetics (120 eyes) were enrolled, with an average age of 62.1 ± 5.24 years. Results: The prognostic value of the percentage expression of CD15+ in ocular surface damage in type 2 diabetics was for the first time evaluated. A rather high sensitivity of the percentage expression of CD15 (88.3%) allows using it as a parameter for screening for the presence of ocular surface damage in type 2 diabetics. Type 2 diabetics with a percentage of >27% of CD15+ cells had 10.52 times increased odds of ocular surface damage (95%CI, 4.34–25.50; p < 0.0001), and this value of the percentage of CD15+ cells can be used for the purpose of screening for ocular surface damage with a sensitivity of 88.3% (95% СІ, 77.8-94.2) and specificity of 63.3% (95% СІ, 50.7-74","PeriodicalId":19419,"journal":{"name":"Oftalmologicheskii zhurnal","volume":"23 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neutrophil activation marker CD15+ as a prognostic factor of ocular surface damage in type 2 diabetics\",\"authors\":\"T. Zhmud, G. Drozhzhyna, L. Velychko\",\"doi\":\"10.31288/oftalmolzh202411519\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: To evaluate the prognostic value of the neutrophil activation marker CD15+ in ocular surface damage in type 2 diabetics. Material and Methods: This study was conducted from January 2021 to January 2021 at the Pirogov Vinnytsia Regional Clinical Hospital, the clinical site of the Medical University. A total of 60 type 2 diabetics (120 eyes) were enrolled, with an average age of 62.1 ± 5.24 years. Results: The prognostic value of the percentage expression of CD15+ in ocular surface damage in type 2 diabetics was for the first time evaluated. A rather high sensitivity of the percentage expression of CD15 (88.3%) allows using it as a parameter for screening for the presence of ocular surface damage in type 2 diabetics. Type 2 diabetics with a percentage of >27% of CD15+ cells had 10.52 times increased odds of ocular surface damage (95%CI, 4.34–25.50; p < 0.0001), and this value of the percentage of CD15+ cells can be used for the purpose of screening for ocular surface damage with a sensitivity of 88.3% (95% СІ, 77.8-94.2) and specificity of 63.3% (95% СІ, 50.7-74\",\"PeriodicalId\":19419,\"journal\":{\"name\":\"Oftalmologicheskii zhurnal\",\"volume\":\"23 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oftalmologicheskii zhurnal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31288/oftalmolzh202411519\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oftalmologicheskii zhurnal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31288/oftalmolzh202411519","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Neutrophil activation marker CD15+ as a prognostic factor of ocular surface damage in type 2 diabetics
Purpose: To evaluate the prognostic value of the neutrophil activation marker CD15+ in ocular surface damage in type 2 diabetics. Material and Methods: This study was conducted from January 2021 to January 2021 at the Pirogov Vinnytsia Regional Clinical Hospital, the clinical site of the Medical University. A total of 60 type 2 diabetics (120 eyes) were enrolled, with an average age of 62.1 ± 5.24 years. Results: The prognostic value of the percentage expression of CD15+ in ocular surface damage in type 2 diabetics was for the first time evaluated. A rather high sensitivity of the percentage expression of CD15 (88.3%) allows using it as a parameter for screening for the presence of ocular surface damage in type 2 diabetics. Type 2 diabetics with a percentage of >27% of CD15+ cells had 10.52 times increased odds of ocular surface damage (95%CI, 4.34–25.50; p < 0.0001), and this value of the percentage of CD15+ cells can be used for the purpose of screening for ocular surface damage with a sensitivity of 88.3% (95% СІ, 77.8-94.2) and specificity of 63.3% (95% СІ, 50.7-74
期刊介绍：
Journal of Ophthalmology (Ukraine) contains articles on eye diseases diagnosis and treatment, eye care, eye diseases prevention, history of ophthalmology, organization of eye care to population, technical equipment problems. It is committed to publishing original scientific researches and review articles on theory and practice of Ukrainian and foreign ophthalmology, cases, reviews, inventions, historical and medical reviews. It contains peer-reviews of books on ophthalmology, articles on activity of ophthalmologic societies, congresses and conferences chronicles. Journal is designed to ophthalmologists and scientific researchers in the field of vision physiology and eye diseases clinic.
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