Catalyst-free Aloe Vera-promoted Cyclization of 2-Amino-azarenes with Phenacyl Bromide

By condensing 2-aminothiazole and phenacyl bromide, a novel catalystfree synthetic approach for the synthesis of imidazo[2,1-b]thiazole derivatives has been developed. In this work, aloe vera/water (3:2) is used as a reusable, environmentally benign, greenpromoting media to synthesize desired products. This method enables the synthesis of a diverse range of aryl-substituted imidazo[2,1-b]thiazoles. This solvent system demonstrates remarkable efficiency and offers numerous advantages, including shorter reaction times, the absence of side product formation, costeffectiveness, excellent atom efficiency, straightforward operation, and high yields. In conclusion, we successfully developed a green protocol for the environmentally benign synthesis of imidazo[2,1-b]thiazole derivatives using aloe vera water as green-promoting media.