N. Simons, A. D. de Ruigh, J. van’t Hooft, C. Aarnoudse-Moens, M. van Wely, D. P. van der Ham, A. V. van Teeffelen, T. J. Roseboom, B. W. Mol, A. Leemhuis, E. Pajkrt
{"title":"早产胎膜早破引产或预产期管理后的儿童结局：PPROMEXIL 试验的 10 年跟踪研究","authors":"N. Simons, A. D. de Ruigh, J. van’t Hooft, C. Aarnoudse-Moens, M. van Wely, D. P. van der Ham, A. V. van Teeffelen, T. J. Roseboom, B. W. Mol, A. Leemhuis, E. Pajkrt","doi":"10.1097/01.aoa.0001005396.47592.ba","DOIUrl":null,"url":null,"abstract":"(Am J Obstet Gynecol. 2023;228:588.e1–588.e13)\n Managing late preterm prelabor rupture of membranes (PPROM) between 34+0 and 36+6 weeks’ gestation helps balance the advantages of extending the pregnancy with the risk of intra-amniotic infection. Two Dutch PPROM Expectant Management Versus Induction of Labor (PPROMEXIL) trials were conducted between 2007 and 2011. These randomized controlled studies analyzed induction of labor (IOL) compared to expectant management (EM) in pregnant women with late PPROM. While neonatal sepsis risks were similar between both groups, children at 2 years of age did show slightly higher neurodevelopmental delays with EM compared to IOL. Long-term data on child development beyond age 2 in children born after late PPROM are lacking. The aim of this PPROMEXIL follow-up study was to evaluate the effects of IOL versus EM on child outcomes.","PeriodicalId":19432,"journal":{"name":"Obstetric Anesthesia Digest","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Childhood Outcomes After Induction of Labor or Expectant Management for Preterm Prelabor Rupture of Membranes: A 10-Year Follow-up of the PPROMEXIL Trials\",\"authors\":\"N. Simons, A. D. de Ruigh, J. van’t Hooft, C. Aarnoudse-Moens, M. van Wely, D. P. van der Ham, A. V. van Teeffelen, T. J. Roseboom, B. W. Mol, A. Leemhuis, E. Pajkrt\",\"doi\":\"10.1097/01.aoa.0001005396.47592.ba\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"(Am J Obstet Gynecol. 2023;228:588.e1–588.e13)\\n Managing late preterm prelabor rupture of membranes (PPROM) between 34+0 and 36+6 weeks’ gestation helps balance the advantages of extending the pregnancy with the risk of intra-amniotic infection. Two Dutch PPROM Expectant Management Versus Induction of Labor (PPROMEXIL) trials were conducted between 2007 and 2011. These randomized controlled studies analyzed induction of labor (IOL) compared to expectant management (EM) in pregnant women with late PPROM. While neonatal sepsis risks were similar between both groups, children at 2 years of age did show slightly higher neurodevelopmental delays with EM compared to IOL. Long-term data on child development beyond age 2 in children born after late PPROM are lacking. The aim of this PPROMEXIL follow-up study was to evaluate the effects of IOL versus EM on child outcomes.\",\"PeriodicalId\":19432,\"journal\":{\"name\":\"Obstetric Anesthesia Digest\",\"volume\":\"29 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obstetric Anesthesia Digest\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/01.aoa.0001005396.47592.ba\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetric Anesthesia Digest","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/01.aoa.0001005396.47592.ba","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Childhood Outcomes After Induction of Labor or Expectant Management for Preterm Prelabor Rupture of Membranes: A 10-Year Follow-up of the PPROMEXIL Trials
(Am J Obstet Gynecol. 2023;228:588.e1–588.e13)
Managing late preterm prelabor rupture of membranes (PPROM) between 34+0 and 36+6 weeks’ gestation helps balance the advantages of extending the pregnancy with the risk of intra-amniotic infection. Two Dutch PPROM Expectant Management Versus Induction of Labor (PPROMEXIL) trials were conducted between 2007 and 2011. These randomized controlled studies analyzed induction of labor (IOL) compared to expectant management (EM) in pregnant women with late PPROM. While neonatal sepsis risks were similar between both groups, children at 2 years of age did show slightly higher neurodevelopmental delays with EM compared to IOL. Long-term data on child development beyond age 2 in children born after late PPROM are lacking. The aim of this PPROMEXIL follow-up study was to evaluate the effects of IOL versus EM on child outcomes.
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