胎儿心率对母体睡眠呼吸紊乱的反应

J.A. DiPietro, J. Bai, F.P. Sgambati, J.L. Henderson, H. Watson, R.S. Raghunathan, G. Pien
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摘要

(Am J Obstet Gynecol.2023;228(4):459.e1-459.e8)妊娠期固有的生理变化会加重潜在的合并症。其中一个常见的问题是睡眠呼吸障碍。睡眠呼吸障碍与妊娠有关的研究发现,睡眠呼吸障碍会导致一系列不良后果,包括妊娠糖尿病、子痫前期、早产和死胎。睡眠呼吸障碍的风险因素往往与其他妊娠并发症的风险因素重叠,因此很难确定两者之间的关系。需要研究的一个领域是睡眠呼吸障碍对胎儿心率(FHR)的影响,胎儿心率是孕期健康的一个指标。本研究旨在探讨肥胖孕妇的睡眠呼吸紊乱对胎儿心率的影响。作者假设呼吸暂停或呼吸减弱会引起可检测到的 FHR 反应,这种反应会在症状更严重的妇女中增强。
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Fetal Heart Rate Responses to Maternal Sleep-Disordered Breathing
(Am J Obstet Gynecol. 2023;228(4):459.e1–459.e8) The physical changes inherent in pregnancy can amplify underlying comorbidities. One common problem worsened in pregnancy is sleep-disordered breathing. Sleep-disordered breathing has been investigated in relation to pregnancy and found to have a host of negative outcomes associated with it, including gestational diabetes, preeclampsia, preterm delivery, and stillbirth. Risk factors for sleep-disordered breathing often overlap with risk factors for other pregnancy complications, and thus relationships can be difficult to characterize. One area needing investigation is the effect of sleep-disordered breathing on fetal heart rate (FHR), which is an indicator of wellbeing during pregnancy. This study was designed to examine the FHR response to sleep-disordered breathing in pregnant women with obesity. The authors hypothesized that apnea or hypopnea would elicit a detectable response in FHR that would be potentiated in women with more severe symptoms.
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