Milind Suryawanshi, V. B. Kumavat, P. Dua, B. Yadav, S. Khanduri, Pallavi S. Mundada, R. Singhal, Rakesh Kumar, Narayanam Srikanth
{"title":"一项多中心研究,评估经典阿育吠陀药物 Vyaghri Haritaki 对支气管哮喘的疗效和安全性","authors":"Milind Suryawanshi, V. B. Kumavat, P. Dua, B. Yadav, S. Khanduri, Pallavi S. Mundada, R. Singhal, Rakesh Kumar, Narayanam Srikanth","doi":"10.56042/ijtk.v23i2.6532","DOIUrl":null,"url":null,"abstract":"Bronchial asthma (vis-à-vis Tamaka Swasa in Ayurveda) is a chronic inflammatory disorder of the airway. Multiple Ayurvedic formulations are prescribed by Ayurveda physicians for Tamak Swasa . Vyaghri Haritaki is one such commonly prescribed poly herbal classical Ayurvedic formulation. A multicentre single-arm study was conducted at three Ayurveda Research Institutes in India to explore the effect and tolerability of Vyaghri Haritaki , a classical Ayurvedic medicine, on bronchial asthma ( Tamaka Swasa ). One forty seven patients between 18 and 60 years diagnosed with bronchial asthma showing a positive test of reversibility of airway obstruction were enrolled. Patients with peak expiratory flow rate (PEFR) < 50% and/ or forced expiratory volume in the first second (FEV1) < 50% of the predicted value and other major co-morbidities were excluded. 10 g Vyaghri Haritaki twice a day with lukewarm water was given for 12 weeks (84 days). Changes in the clinical symptoms (Asthma Control Questionnaire), quality of life (St. George Respiratory Questionnaire), respiratory function (peak expiratory flow rate and forced expiratory volume in one second), and haematological and biochemical parameters were compared before and after the treatment. Data of 142 participants were analysed which revealed significant improvement in PEFR [Baseline 301.7 litre/minute and 84 th Day 334.85 litre/minute (p<0.001)], FEV1 [Baseline 1.83 litres and 84 th Day 2.12 litres (p<0.001)], Asthma Control Questionnaire [Baseline 2.95 and 84 th Day 1.43 (p<0.001)], and the total score of the St. George Respiratory Questionnaire [Baseline 50.46 and 84 th Day 30.74 (p<0.001)]. No adverse events were reported during the study. Vyaghri Haritaki may prove beneficial in improving the pulmonary function, overall symptoms, and quality of life of patients with bronchial asthma which is well tolerated.","PeriodicalId":56294,"journal":{"name":"Indian Journal of Traditional Knowledge","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A multi-centre study to evaluate the effect and safety of a classical Ayurveda medicine Vyaghri Haritaki in bronchial asthma\",\"authors\":\"Milind Suryawanshi, V. B. Kumavat, P. Dua, B. Yadav, S. Khanduri, Pallavi S. Mundada, R. Singhal, Rakesh Kumar, Narayanam Srikanth\",\"doi\":\"10.56042/ijtk.v23i2.6532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Bronchial asthma (vis-à-vis Tamaka Swasa in Ayurveda) is a chronic inflammatory disorder of the airway. Multiple Ayurvedic formulations are prescribed by Ayurveda physicians for Tamak Swasa . Vyaghri Haritaki is one such commonly prescribed poly herbal classical Ayurvedic formulation. A multicentre single-arm study was conducted at three Ayurveda Research Institutes in India to explore the effect and tolerability of Vyaghri Haritaki , a classical Ayurvedic medicine, on bronchial asthma ( Tamaka Swasa ). One forty seven patients between 18 and 60 years diagnosed with bronchial asthma showing a positive test of reversibility of airway obstruction were enrolled. Patients with peak expiratory flow rate (PEFR) < 50% and/ or forced expiratory volume in the first second (FEV1) < 50% of the predicted value and other major co-morbidities were excluded. 10 g Vyaghri Haritaki twice a day with lukewarm water was given for 12 weeks (84 days). Changes in the clinical symptoms (Asthma Control Questionnaire), quality of life (St. George Respiratory Questionnaire), respiratory function (peak expiratory flow rate and forced expiratory volume in one second), and haematological and biochemical parameters were compared before and after the treatment. Data of 142 participants were analysed which revealed significant improvement in PEFR [Baseline 301.7 litre/minute and 84 th Day 334.85 litre/minute (p<0.001)], FEV1 [Baseline 1.83 litres and 84 th Day 2.12 litres (p<0.001)], Asthma Control Questionnaire [Baseline 2.95 and 84 th Day 1.43 (p<0.001)], and the total score of the St. George Respiratory Questionnaire [Baseline 50.46 and 84 th Day 30.74 (p<0.001)]. No adverse events were reported during the study. Vyaghri Haritaki may prove beneficial in improving the pulmonary function, overall symptoms, and quality of life of patients with bronchial asthma which is well tolerated.\",\"PeriodicalId\":56294,\"journal\":{\"name\":\"Indian Journal of Traditional Knowledge\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Traditional Knowledge\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.56042/ijtk.v23i2.6532\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Traditional Knowledge","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.56042/ijtk.v23i2.6532","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
A multi-centre study to evaluate the effect and safety of a classical Ayurveda medicine Vyaghri Haritaki in bronchial asthma
Bronchial asthma (vis-à-vis Tamaka Swasa in Ayurveda) is a chronic inflammatory disorder of the airway. Multiple Ayurvedic formulations are prescribed by Ayurveda physicians for Tamak Swasa . Vyaghri Haritaki is one such commonly prescribed poly herbal classical Ayurvedic formulation. A multicentre single-arm study was conducted at three Ayurveda Research Institutes in India to explore the effect and tolerability of Vyaghri Haritaki , a classical Ayurvedic medicine, on bronchial asthma ( Tamaka Swasa ). One forty seven patients between 18 and 60 years diagnosed with bronchial asthma showing a positive test of reversibility of airway obstruction were enrolled. Patients with peak expiratory flow rate (PEFR) < 50% and/ or forced expiratory volume in the first second (FEV1) < 50% of the predicted value and other major co-morbidities were excluded. 10 g Vyaghri Haritaki twice a day with lukewarm water was given for 12 weeks (84 days). Changes in the clinical symptoms (Asthma Control Questionnaire), quality of life (St. George Respiratory Questionnaire), respiratory function (peak expiratory flow rate and forced expiratory volume in one second), and haematological and biochemical parameters were compared before and after the treatment. Data of 142 participants were analysed which revealed significant improvement in PEFR [Baseline 301.7 litre/minute and 84 th Day 334.85 litre/minute (p<0.001)], FEV1 [Baseline 1.83 litres and 84 th Day 2.12 litres (p<0.001)], Asthma Control Questionnaire [Baseline 2.95 and 84 th Day 1.43 (p<0.001)], and the total score of the St. George Respiratory Questionnaire [Baseline 50.46 and 84 th Day 30.74 (p<0.001)]. No adverse events were reported during the study. Vyaghri Haritaki may prove beneficial in improving the pulmonary function, overall symptoms, and quality of life of patients with bronchial asthma which is well tolerated.
期刊介绍:
Traditional knowledge" is employed to mean knowledge, innovations and practices of indigenous and local communities embodying traditional life-styles; the wisdom developed over many generations of holistic traditional scientific utilization of the lands, natural resources, and environment. It is generally passed down by word of mouth, from generation to generation and is, for the most part, undocumented. Traditional knowledge is valid and necessary, and awaits its currently relevant wider application for human benefit. National Institute of Science Communication and Information Resources, CSIR felt a need to document the recent developments and the information bygone in this area in the form of an interdisciplinary periodical.
The Indian Journal of Traditional Knowledge will carry original research papers, review articles, short communications, etc. concerned with the observation and experimental investigation of the biological activities of the materials from plants, animals and minerals, used in the traditional health-care systems such as Ayurveda, Siddha, Yoga, Unani, Naturopathy, Homoeopathy, Folk-remedies, etc. As validation of indigenous claims it will cover Ethno-biology, Ethno-medicine, Ethno-pharmacology, Ethno-pharmacognosy & Clinical Studies on efficacy .