重新定义血清阳性类风湿性关节炎：抗淀粉样蛋白对缓解、放射损伤和生活质量的临床影响

Annals of the Academy of Medicine, Singapore Pub Date : 2024-01-30 DOI:10.47102/annals-acadmedsg.2023112

Jiacai Cho, Anselm Mak, Sachin Agrawal, P. Dhanasekaran, Peter P Cheun, Manjari Lahiri

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引用次数: 0

摘要

类风湿性关节炎（RA）是一种慢性致残性疾病，持续的疾病活动会导致不可逆的关节损伤。类风湿因子（RF）和抗瓜氨酸蛋白抗体（ACPA）血清阳性是预后较差的标志，会导致疾病活动增加、影像学进展甚至死亡。

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Redefining seropositive rheumatoid arthritis: Clinical implications of anti-carbamylated protein on remission, radiographic damage and quality of life

Rheumatoid arthritis (RA) is a chronic disabling disease where continued disease activity translates to irreversible articular damage. Seropositivity for rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) are markers of poorer prognosis; with increased disease activity, radiographic progression and even mortality.1 However, other than ACPA, no other biomarker has emerged for clinical use in the last 10 years.

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Annals of the Academy of Medicine, Singapore

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