Phyllanthus-derived Naturally-occurring Products: An Overview of Their Effects against Viruses in Cell Models

Infectious diseases are considered a global public health problem, with viruses being the predominant infectious agents afflicting the human population. The most used control alternatives are the search and development of vaccines and drugs. Nevertheless, their efficacy has limitations related to the immune response stimulation, resistance mechanisms, costeffort ratio, development, and production. An alternative to these drawbacks is the search for compounds isolated from plants with antiviral and/or virucidal properties. The genus Phyllanthus is a plant group producing compounds that gathers an antiviral and virucidal spectrum on different biological models. However, there is no complete review of their properties against viruses in cell models. To compile and analyse the more relevant information on the antiviral and virucidal activity in cell models, phytochemical composition, and generalities of the genus Phyllanthus. The information was assembled from a general search for articles in various databanks, and the information was organized, tabulated, and discussed. The taxonomic classification of the genus Phyllanthus showed discrepancies between different authors and publications. The antiviral and virucidal effects of Phyllanthus naturallyoccurring compounds on cell models showed a broad spectrum and a high chemical diversity mainly related to phenols and polyphenols. Antiviral and virucidal properties of Phyllanthus-derived compounds showed promising results as controlling agents against viral infections in different cell models, particularly in the viral replication and translation processes. Further studies are required to elucidate the specific mechanisms involved in these natural alternatives to expand their efficient and effective applications.