日惹格哈西娅精神病院利培酮的使用和副作用研究

Bangunawati Rahajeng, Salman Akbar
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摘要

利培酮是一种非典型抗精神病药物,适用于急性和慢性精神分裂症和躁狂症。一项研究发现,利培酮用于治疗急性精神分裂症的比例为 25.32%。利培酮的副作用包括失眠、焦虑、头痛和锥体外系症状。由于利培酮的使用率较高,且可能存在多种副作用,因此有必要对该药物进行研究。本研究旨在描述利培酮在日惹格拉西亚精神病院的使用情况和副作用。本研究为非实验性研究,采用描述性设计。数据是从日惹格拉西亚精神病医院2019年1月至12月接受利培酮处方的患者的病历中回顾性收集的。抽样采用目的性抽样技术,共获得 360 个样本。副作用发生率采用纳兰霍算法进行分析。日惹格拉西亚精神病院利培酮的使用情况显示,患者病情好转的占25.83%,病情好转但必须控制的占71.17%。在服用利培酮的 360 名患者中,副作用发生率为 15%。最常见的副作用是震颤(4.72%)、失眠(2.50%)、恶心(1.67%)和呕吐(1.39%)。在治疗副作用时,65%的患者接受了额外治疗,22%的患者没有接受额外治疗,13%的患者停药。结论在日惹格拉西亚医院使用利培酮显示出良好的疗效,如果处理得当,副作用发生率为 15%。
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KAJIAN PENGGUNAAN DAN EFEK SAMPING RISPERIDONE DI RUMAH SAKIT JIWA GRHASIA YOGYAKARTA
Risperidone is an atypical antipsychotic indicated for acute and chronic schizophrenia and mania. A study found that the use of risperidone as a therapy for acute schizophrenia was 25.32%. Side effects of risperidone include insomnia, anxiety, headache, and extrapyramidal symptoms. With the high use of risperidone and the many possible side effects, it is necessary to study the drug. This study aims to describe the use and side effects of risperidone at the Ghrasia Mental Hospital Yogyakarta. This research is non-experimental research using a descriptive design. Data were collected retrospectively from medical records of a patient who received risperidone prescriptions at the Grhasia Mental Hospital Yogyakarta January-December 2019. Sampling used the purposive sampling technique, and 360 samples were obtained. The incidence of side effects was analyzed using the Naranjo algorithm. The use of risperidone at the Ghrasia Mental Hospital Yogyakarta showed that patients improved 25.83%, patients improved but had to control 71.17%. The incidence of side effects was 15% of the total 360 patients taking risperidone. The most common side effects were tremor (4.72%), insomnia 2.50%, nausea 1.67%, and vomiting 1.39%. Side effects were treated with 65% additional therapy, 22% no additional therapy, and 13% drug discontinuation. Conclusion: The use of risperidone at Ghrasia Hospital Yogyakarta shows good effectiveness with a 15% incidence of side effects that are handled properly
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