O. V. Kalinina, D. B. Sambur, E. E. Koroleva, A. S. Golovkin
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Zebrafish as a model for studing extracellular vesicles.
It was evaluated the feasibility of using Zebrafish as a model to study extracellular vesicles (EVs) based on literature. Particularly, it was described experimental models that were used to assess the contribution of the EVs in the regulation of pathological and physiological processes (ischemic, reperfusion, mechanical damage to tissues and organs, development of local and systemic immune response, tumor growth and metastasis, etc.), the bioavailability and the distribution of injected EVs in different tissues and organs, the effects of exogenous EVs as therapeutic agents.
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