心血管疾病不同阶段的肠道微生物群

A. Yafarova, E. D. Dementyeva, O. A. Zlobovskaya, A. R. Kiselev, A. Sheptulina, G. A. Ashniev, L. M. Zhamalov, V. Makarov, S. Yudin, O. Drapkina
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引用次数: 0

摘要

目的研究冠状动脉疾病(CAD)和射血分数降低型心力衰竭(HFrEF)患者的肠道微生物群(GM)组成与临床和辅助临床特征的关系。研究对象包括 64 名(男性,71.9%)冠状动脉疾病患者、33 名(男性,87.9%)射血分数降低性心力衰竭患者和 38 名(男性,63.2%)具有各种心血管风险因素的患者(对照组)。采用实时聚合酶链式反应和新一代测序技术对基因改造成分进行了评估。为了确定基因组成分与临床和准临床特征的相关性,计算了斯皮尔曼秩相关系数(ρ)。使用带有协变量(年龄、体重指数)的广义线性模型(QuasiPoisson,过度分散)对各组进行系统型比较。与对照组相比,CAD 和 HFrEF 患者的芽孢杆菌系统型相对丰度明显更高(P<0.001)。CAD 和 HFrEF 患者的芽生菌群/类菌群菌群失调比率也明显高于对照组(p<0,001)。根据相关性分析,甲烷化古细菌甲烷菌科(Methanomassiliicoccaceae)和嗜甲烷菌科(Methanomethylophilaceae)的相对代表性(ρ=0,49,p<0,0003)与高频率心衰患者的室性心律失常直接相关。在系统型水平上,CAD 和 HFrEF 患者的基因组组成与对照组有显著差异。在研究组中,芽孢杆菌群/类杆菌群菌群失调比例也明显高于对照组。古细菌甲壳质球菌科(Methanomassiliicoccaceae)和嗜甲壳质球菌科(Methanomethylophilaceae)的相对丰度与室性心动过速/室颤的发作有关。
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Gut microbiota at different stages of cardiovascular disease continuum
Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.
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来源期刊
Cardiovascular Therapy and Prevention
Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.70
自引率
0.00%
发文量
155
审稿时长
6-12 weeks
期刊介绍: The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.
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