Oxomorpholine-Imidazole 衍生物的快速合成和综合表征:揭示其显著的抗菌活性

S. M. Sitapara, J. H. Pandya, S. K. Kangad
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引用次数: 0

摘要

这项研究的重点是合成具有潜在制药和药用价值的芳香族或杂芳族化合物。咪唑衍生物具有多种治疗潜力,可治疗癌症、细菌感染、真菌感染和疟疾等多种疾病,因此备受关注。为了实现这一目标,我们开发了一条高效的合成路线,以探索多种 2-((1,4-二苯基-1H-咪唑-2-基)硫基)-N-(4-(3-氧代吗啉基)苯基)乙酰胺衍生物。利用 1H 和 13C NMR、FT-IR 光谱、质谱和元素分析等先进技术对合成化合物进行了结构阐释。此外,本研究中合成的氧代吗啉咪唑衍生物还被进一步用于生产多种化疗药物,具有巨大的临床应用潜力。
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Expedited Synthesis and Comprehensive Characterization of Oxomorpholine-Imidazole Derivatives: Unraveling their Remarkable Antimicrobial Activity
This research focuses on synthesizing aromatic or heteroaromatic compounds with potential pharmaceutical and medicinal applications. Imidazole derivatives have garnered significant attention due to their versatile therapeutic potential, encompassing a broad spectrum of diseases, including cancer, bacterial infections, fungal infections, and malaria. To accomplish this, we have developed an efficient synthetic route to explore a diverse array of 2-((1,4-diphenyl-1H-imidazol-2-yl)thio)-N-(4-(3-oxomorpholino)phenyl) acetamide  derivatives. The structural elucidation of the synthesized compounds was carried out using advanced techniques, including 1H and 13C NMR, FT-IR spectroscopy, mass spectroscopy, and elemental analysis. Furthermore, the oxo morpholino-imidazole derivatives synthesized in this study were further employed to produce diverse chemotherapeutic agents with significant potential for clinical applications.             
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审稿时长
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