{"title":"Oxomorpholine-Imidazole 衍生物的快速合成和综合表征:揭示其显著的抗菌活性","authors":"S. M. Sitapara, J. H. Pandya, S. K. Kangad","doi":"10.3329/jsr.v16i1.67728","DOIUrl":null,"url":null,"abstract":"This research focuses on synthesizing aromatic or heteroaromatic compounds with potential pharmaceutical and medicinal applications. Imidazole derivatives have garnered significant attention due to their versatile therapeutic potential, encompassing a broad spectrum of diseases, including cancer, bacterial infections, fungal infections, and malaria. To accomplish this, we have developed an efficient synthetic route to explore a diverse array of 2-((1,4-diphenyl-1H-imidazol-2-yl)thio)-N-(4-(3-oxomorpholino)phenyl) acetamide derivatives. The structural elucidation of the synthesized compounds was carried out using advanced techniques, including 1H and 13C NMR, FT-IR spectroscopy, mass spectroscopy, and elemental analysis. Furthermore, the oxo morpholino-imidazole derivatives synthesized in this study were further employed to produce diverse chemotherapeutic agents with significant potential for clinical applications.\n ","PeriodicalId":16984,"journal":{"name":"JOURNAL OF SCIENTIFIC RESEARCH","volume":"4 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expedited Synthesis and Comprehensive Characterization of Oxomorpholine-Imidazole Derivatives: Unraveling their Remarkable Antimicrobial Activity\",\"authors\":\"S. M. Sitapara, J. H. Pandya, S. K. Kangad\",\"doi\":\"10.3329/jsr.v16i1.67728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This research focuses on synthesizing aromatic or heteroaromatic compounds with potential pharmaceutical and medicinal applications. Imidazole derivatives have garnered significant attention due to their versatile therapeutic potential, encompassing a broad spectrum of diseases, including cancer, bacterial infections, fungal infections, and malaria. To accomplish this, we have developed an efficient synthetic route to explore a diverse array of 2-((1,4-diphenyl-1H-imidazol-2-yl)thio)-N-(4-(3-oxomorpholino)phenyl) acetamide derivatives. The structural elucidation of the synthesized compounds was carried out using advanced techniques, including 1H and 13C NMR, FT-IR spectroscopy, mass spectroscopy, and elemental analysis. Furthermore, the oxo morpholino-imidazole derivatives synthesized in this study were further employed to produce diverse chemotherapeutic agents with significant potential for clinical applications.\\n \",\"PeriodicalId\":16984,\"journal\":{\"name\":\"JOURNAL OF SCIENTIFIC RESEARCH\",\"volume\":\"4 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOURNAL OF SCIENTIFIC RESEARCH\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/jsr.v16i1.67728\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF SCIENTIFIC RESEARCH","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/jsr.v16i1.67728","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Expedited Synthesis and Comprehensive Characterization of Oxomorpholine-Imidazole Derivatives: Unraveling their Remarkable Antimicrobial Activity
This research focuses on synthesizing aromatic or heteroaromatic compounds with potential pharmaceutical and medicinal applications. Imidazole derivatives have garnered significant attention due to their versatile therapeutic potential, encompassing a broad spectrum of diseases, including cancer, bacterial infections, fungal infections, and malaria. To accomplish this, we have developed an efficient synthetic route to explore a diverse array of 2-((1,4-diphenyl-1H-imidazol-2-yl)thio)-N-(4-(3-oxomorpholino)phenyl) acetamide derivatives. The structural elucidation of the synthesized compounds was carried out using advanced techniques, including 1H and 13C NMR, FT-IR spectroscopy, mass spectroscopy, and elemental analysis. Furthermore, the oxo morpholino-imidazole derivatives synthesized in this study were further employed to produce diverse chemotherapeutic agents with significant potential for clinical applications.