OUTCOME OF MANAGEMENT OF INVASIVE LOBULAR CARCINOMA IN COMPARISON TO INVASIVE DUCT CARCINOMA

Background : Among females, breast cancer has the highest incidence and is the leading cause of cancer-related death globally. Aim : In contrast to invasive lobular carcinoma (ILC), the objective of this research is to examine how invasive duct carcinoma (IDC) is managed. Patient and methods : This examined 200 women who were registered in the Al-Azhar University Hospitals database between January 2020 and December 2022 and were diagnosed with nonmetastatic invasive breast cancer. The current investigation included cases with IDC or ILC histology based on the WHO classi fi cation ' s criteria. Results : The patient met the criteria for M0 illness by undergoing primary curative breast surgery, of which 170 (85%) were classi fi ed as IDC and 17 (8.5%) as ILC. The remaining patients were ruled out of further research due to their diagnosis of different histological subtypes, 13 of which had mixed ILC and IDC. Cases with ILC were offered mastectomy more often than those with IDC (79.4 vs. 67.7%). ILC cases had lower levels of human epidermal growth factor receptor 2 positivity (9 vs. 18%) but higher levels of estrogen receptor-positive illness (83 vs. 70%) and progesterone receptor-positive disease (75 vs. 60%) when compared with IDC individuals. Conclusion : ILC has unique biologic and prognostic characteristics that may call for various treatment modalities.