铁蛋白与 COVID-19 血液透析患者的死亡率：系统回顾和荟萃分析

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Asian Pacific journal of tropical medicine Pub Date : 2024-01-01 DOI:10.4103/apjtm.apjtm_624_23

Ni Wayan Anantika Riani, I. Widiana, Y. Kandarini

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引用次数: 0

摘要

研究 COVID-19 已故和存活的定期血液透析患者血清铁蛋白水平的差异。我们按照 PRISMA 声明指南在四个数据库中进行了系统检索。纳入了报告 COVID-19 定期血液透析患者铁蛋白水平和死亡率的研究。我们采用随机效应模型进行了荟萃分析，以确定研究组间血清铁蛋白水平的平均差异及其相应的 95% 置信区间。荟萃分析使用 Review Manager 5.4 和 Stata 16 进行。本研究共纳入了 7 项研究中的 1 013 名患者。我们的荟萃分析表明，与存活的常规血液透析患者相比，COVID-19 死亡患者的平均血清铁蛋白更高，平均差异为 449.43 ng/mL [95% CI (244.07, 654.80), P<0.000 1; I 2=58%, P=0.003]。我们的研究发现，与COVID-19存活的普通血液透析患者相比，已故患者的血清铁蛋白平均水平更高。

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Ferritin and mortality in hemodialysis patients with COVID-19: A systematic review and meta-analysis

To investigate the difference in serum ferritin levels between deceased and surviving regular hemodialysis patients with COVID-19. We conducted a systematic search across four databases following the PRISMA statement guidelines. Studies reporting ferritin levels and mortality of regular hemodialysis patients with COVID-19 were included. Employing the random-effects model, we performed a meta-analysis to determine the mean difference in serum ferritin levels between the studied groups, along with their corresponding 95% confidence intervals. The meta-analysis was carried out using Review Manager 5.4 and Stata 16. A total of 1 013 patients from seven studies were included in this study. Our meta-analysis showed higher mean serum ferritin in the deceased compared to surviving regular hemodialysis patients with COVID-19, with a mean difference of 449.43 ng/mL [95% CI (244.07, 654.80), P<0.000 1; I 2=58%, P=0.003]. Our study found a higher mean of serum ferritin levels in the deceased compared to surviving regular hemodialysis patients with COVID-19.

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来源期刊

Asian Pacific journal of tropical medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-TROPICAL MEDICINE

CiteScore

4.00

自引率

9.70%

发文量

1936

审稿时长

3-8 weeks

期刊介绍： Asian Pacific Journal of Tropical Medicine (ISSN 1995-7645 CODEN: APJTB6), a publication of Editorial office of Hainan Medical University,is a peer-reviewed print + online Monthly journal. The journal''s full text is available online at http://www.apjtm.org/. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. APJTM aims to provide an academic communicating platform for international physicians, medical scientists, allied health scientists and public health workers, especially those of the Asia-Pacific region and worldwide on tropical medicine, infectious diseases and public health, and to meet the growing challenges of understanding, preventing and controlling the dramatic global emergence and re-emergence of infectious diseases in the Asia-Pacific. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on tropical medicine, infectious diseases and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. The APJTM will allow us to seek opportunities to work with others who share our aim, and to enhance our work through partnership, and to uphold the standards of our profession and contribute to its advancement.