捕食者气味应激反应、饮酒和内源性大麻素系统

IF 4.3 2区 医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2024-04-04 DOI:10.1016/j.ynstr.2024.100634
Laura C. Ornelas , Joyce Besheer
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引用次数: 0

摘要

创伤后应激障碍(PTSD)和酒精使用障碍(AUD)是高度并发症,对应激反应的个体差异表明有适应能力的人群和易受影响的人群。利用动物模型瞄准与压力应对反应个体差异相关的神经生物学机制以及与随后酒精消费增加的关系,对创伤应激障碍和酒精紊乱领域具有重要意义。本综述讨论了利用捕食者气味应激源暴露模型的独特优势,特别是利用 2,5-二氢-2,4,5-三甲基噻唑啉(TMT)来更好地了解创伤后应激障碍的病理生理学以及与应激反应性和随后的饮酒增加有关的神经生物学机制。此外,人们越来越关注内源性大麻素系统在调节应激行为反应中的作用,重点是应激应对和应激易感性的个体差异。因此,本综述将重点放在内源性大麻素对暴露于捕食者气味应激源期间和之后的应激反应行为的调节作用,以及对调节截然不同的行为应对策略的影响。
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Predator odor stress reactivity, alcohol drinking and the endocannabinoid system

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid and individual differences in response to stress suggest resilient and susceptible populations. Using animal models to target neurobiological mechanisms associated with individual variability in stress coping responses and the relationship with subsequent increases in alcohol consumption has important implications for the field of traumatic stress and alcohol disorders. The current review discusses the unique advantages of utilizing predator odor stressor exposure models, specifically using 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) on better understanding PTSD pathophysiology and neurobiological mechanisms associated with stress reactivity and subsequent increases in alcohol drinking. Furthermore, there has been increasing interest regarding the role of the endocannabinoid system in modulating behavioral responses to stress with an emphasis on stress coping and individual differences in stress-susceptibility. Therefore, the current review focuses on the topic of endocannabinoid modulation of stress reactive behaviors during and after exposure to a predator odor stressor, with implications on modulating distinctly different behavioral coping strategies.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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