接受 EV 与化疗的患者的 HRQoL

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-04-16 DOI:10.1038/s41585-024-00882-y
Maria Chiara Masone
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引用次数: 0

摘要

在 EV-301 III 期试验中,与化疗相比,恩福单抗维多汀(EV)可提高曾接受过化疗并在接受 PD1 或 PDL1 抑制剂治疗后出现疾病进展的转移性尿路上皮癌患者的总生存期。发表在《欧洲泌尿学》(European Urology)上的一项研究对这些患者的健康相关生活质量(HRQoL)进行了患者报告结果(PRO)分析评估。具体来说,该研究评估了经过验证的欧洲癌症研究和治疗组织生活质量问卷核心30(QLQ-C30)从基线到第12周的变化。使用 EV 后,患者的 HRQoL 得到了维持,疼痛减轻方面的改善最为显著(P = 0.027)。应答者分析结果显示,在大多数 QLQ-C30 症状量表(15 项中的 10 项)中,接受 EV 治疗的患者比接受化疗的患者有更多的改善。尽管作者承认这项研究存在一些局限性,包括由于患者死亡导致完成率下降,但这些PRO数据支持EV-301试验的安全性和有效性结果,并可用于临床实践,补充共同决策。
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HRQoL in patients receiving EV versus chemotherapy
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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