原发性高草酸尿症发病机制的分子之旅。

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE Current Opinion in Nephrology and Hypertension Pub Date : 2024-04-12 DOI:10.1097/mnh.0000000000000987

Barbara Cellini

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引用次数: 0

摘要

原发性草酸过多症（PHs）是一种罕见的疾病，是由于肝脏中参与乙醛酸代谢的酶缺乏而引起的。其主要特征是草酸盐排泄增加，导致草酸钙结石在尿路沉积。本综述介绍了 PHs 的分子方面及其与患者临床治疗的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A molecular journey on the pathogenesis of primary hyperoxaluria.

Primary hyperoxalurias (PHs) are rare disorders caused by the deficit of liver enzymes involved in glyoxylate metabolism. Their main hallmark is the increased excretion of oxalate leading to the deposition of calcium oxalate stones in the urinary tract. This review describes the molecular aspects of PHs and their relevance for the clinical management of patients.

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.