在实验室或自由生活条件下,坐姿膝关节屈曲角度不会影响内皮依赖性血管扩张作用

IF 3 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE Vascular Medicine Pub Date : 2024-04-10 DOI:10.1177/1358863x241238702
Madeline E Shivgulam, Myles W O’Brien, Yanlin Wu, Haoxuan Liu, Jennifer L Petterson, Beverly D Schwartz, Derek S Kimmerly
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引用次数: 0

摘要

导言:单次长时间弯腿坐姿会减弱腘绳肌内皮依赖性血管扩张(通过血流介导的扩张[FMD]进行评估),其部分原因是动脉 "扭结"。然而,膝关节屈曲角度对坐姿诱导的腘绳肌FMD的影响尚不清楚。本研究的目的是分别进行实验室研究和自由生活研究,以验证以下假设:(1) 在坐立 3 小时后,膝关节屈曲 90°(屈腿坐立)> 45°>0°(直腿坐立)时,腘窝 FMD 损伤将分级;(2) 习惯屈腿坐立(< 45°)的时间越长,FMD 越低。方法:这项实验室研究包括 8 名年轻、健康的成年人(24 ± 2 岁;4 名女性),他们在 2 天内进行了两次坐姿训练,其中一条腿的膝关节屈曲角度为 0° 或 90°,另一条腿的膝关节屈曲角度为 45°。结果:在所有膝关节屈曲角度下,久坐引起的 FMD 减少情况相似(所有情况下,P 均为 0.674)。自由生活研究包括 35 名年轻、健康的成年人(23 ± 3 岁;16 名女性),他们佩戴了三个 activPAL 监测器(躯干、大腿、胫骨),以确定详细的久坐姿势。久坐时间(624 ± 127 分钟/天)、直腿坐姿(112 ± 98 分钟/天)和弯腿坐姿(442 ± 106 分钟/天)与相对 FMD(5.3 ± 1.8%;全部,p > 0.240)无关。
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Sitting knee-flexion angle does not influence endothelial-dependent vasodilation in laboratory or free-living conditions
Introduction:Single bouts of prolonged bent-legged sitting attenuate popliteal endothelial-dependent vasodilation (as assessed via flow-mediated dilation [FMD]), which is partially attributed to arterial ‘kinking’. However, the impact of knee-flexion angle on sitting-induced popliteal FMD is unknown. The objective of this study was to perform separate laboratory and free-living studies to test the hypotheses that: (1) popliteal FMD impairments would be graded between knee flexions at 90° (bent-legged sitting) > 45° > 0° (straight-legged sitting) following a 3-hour bout of sitting; and (2) more habitual time spent bent-legged sitting (< 45°) would be associated with lower FMD.Methods:The laboratory study included eight young, healthy adults (24 ± 2 years; four women) who underwent two sitting bouts over 2 days with one leg positioned at a knee-flexion angle of 0° or 90° and the opposite leg at 45° knee flexion. Popliteal FMD was assessed at pre- and postsitting timepoints.Results:Sitting-induced reductions in FMD were similar between all knee-flexion angles (all, p > 0.674). The free-living study included 35 young, healthy adults (23 ± 3 years; 16 women) who wore three activPAL monitors (torso, thigh, shin) to determine detailed sedentary postures. Time spent sedentary (624 ± 127 min/day), straight-legged sitting (112 ± 98 min/day), and bent-legged sitting (442 ± 106 min/day) were not related to relative FMD (5.3 ± 1.8%; all, p > 0.240).Conclusion:These findings suggest that knee-flexion angle-mediated arterial ‘kinking’ during sitting is not a major contributor toward sitting-induced popliteal endothelial-dependent vasodilatory dysfunction.
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来源期刊
Vascular Medicine
Vascular Medicine 医学-外周血管病
CiteScore
5.70
自引率
5.70%
发文量
158
审稿时长
>12 weeks
期刊介绍: The premier, ISI-ranked journal of vascular medicine. Integrates the latest research in vascular biology with advancements for the practice of vascular medicine and vascular surgery. It features original research and reviews on vascular biology, epidemiology, diagnosis, medical treatment and interventions for vascular disease. A member of the Committee on Publication Ethics (COPE)
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