根据 ASAS 和超声波检查得出的炎症性肠病脊柱关节炎患病率及其与血浆钙蛋白的相关性

IF 2 4区 医学 Q3 RHEUMATOLOGY Advances in Rheumatology Pub Date : 2024-04-15 DOI:10.1186/s42358-023-00348-6
Míriam Küster Huber, Valeria Valim, Érica Vieira Serrano, José Alexandre Mendonça, Rafael Burgomeister Lourenço, Thaisa Moraes Ribeiro Espírito Santo, Hilde Nordal, Maria de Fátima Bissoli, Maria Bernadete Renoldi de Oliveira Gavi
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引用次数: 0

摘要

肠病性脊柱关节炎诊断率低,而炎症生物标志物和超声波检查(US)可用于筛查炎症性肠病(IBD)患者。本研究的目的是根据脊柱关节炎国际协会(ASAS)的评估标准,评估脊柱关节炎(SpondyloArthritis,SPA)在 IBD 患者中的患病率,以及粘膜和关节超声检查结果与血浆钙蛋白水平的相关性。这是一项观察性横断面研究。参照中心的 IBD 门诊根据 ASAS 标准分类、内膜和关节 US 检测结果以及炎症生物标志物测量结果(红细胞沉降率、C 反应蛋白水平、粪便和血浆钙蛋白水平)对患者进行了评估。P 值低于 0.05 即为显著。在所研究的样本(n = 118)中,共有 30.5% 的 IBD 患者至少有一种炎症性肌肉骨骼表现。根据 ASAS 标准,肠病性 SpA 的总发病率为 13.55%,其中 10.16% 为轴向 SpA,4.23% 为周围 SpA。共有42.1%的患者的MASEI评分大于18分,35.2%的患者患有滑膜炎,14.7%的患者在US检查中发现了腱鞘炎,这使得肠病性斯巴炎的诊断率增加到22.8%。血浆钙蛋白水平与健康对照组相似,仅与粪便钙蛋白水平相关(P 0.041)。根据 ASAS 标准,共有 13.5% 的患者符合肠病性脊柱炎的标准,加上 US 标准后,这一比例增至 22.8%。通过对有症状的关节和夹缝进行US检查,发现夹缝炎、滑膜炎和腱鞘炎的发病率分别为42%、35%和14.7%。血浆钙蛋白与粪便钙蛋白相关,但与炎症生物标志物或 US 或 ASAS 标准无关。
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Prevalence of spondyloarthritis in inflammatory bowel disease according ASAS and ultrassonography and its correlation with plasma calprotectin
Enteropathic spondyloarthritis is underdiagnosed and inflammatory biomarkers and ultrasonography (US) could be useful for screening inflammatory bowel disease (IBD) patients. The objective of this study was to evaluate the prevalence of spondyloarthritis (SpA) in IBD patients, according to the Assessment of SpondyloArthritis International Society (ASAS) criteria and the correlation of results of US of entheses and joints with plasma calprotectin levels. This was an observational cross-sectional study. Patients from the IBD outpatient clinic of a reference center were evaluated according to ASAS criteria classification, results of US of entheses and joints, and inflammatory biomarker measurements (erythrocyte sedimentation rates, C-reactive protein levels, fecal and plasma calprotectin levels). A p value lower than 0.05 was considered significant. A total of 30.5% of the studied sample (n = 118) of patients with IBD presented at least one inflammatory musculoskeletal manifestation. The overall prevalence of enteropathic SpA was 13.55%, with 10.16% axial SpA and 4.23% peripheral SpA according to the ASAS criteria. A total of 42.1% of patients had an MASEI score greater than 18, 35.2% had synovitis, and 14.7% had tenosynovitis on US, increasing the frequency of diagnosis of enteropathic SpA to 22.8%. Plasma calprotectin levels were similar to those in healthy controls, and correlated only with the fecal calprotectin level (p 0.041). A total of 13.5% of patients met the criteria in accordance with the ASAS criteria for enteropathic SpA, which increased to 22.8% with the addition of US. The prevalence of enthesitis, synovitis and tenosynovitis by US of symptomatic joints and entheses were 42%, 35% and 14.7% respectively. Plasma calprotectin was correlated with fecal calprotectin but not with inflammatory biomarkers or US or ASAS criteria.
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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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