Nicholas A. Deebel, Ashley N. Matthew, Justin Loloi, Ari P. Bernstein, Nannan Thirumavalavan, Ranjith Ramasamy
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引用次数: 0
摘要
睾酮缺乏症是一种常见病,经常影响终末期肾病(ESRD)患者和接受肾移植的患者。虽然这种疾病的病因很复杂,但它对这一人群的影响却很深远,会影响内分泌状况、性功能和勃起功能、骨矿物质密度(BMD)、贫血以及肾移植后的移植物存活率等多个方面。在此,我们回顾了最新的文献,这些文献探讨了 ESRD 和肾移植患者睾酮缺乏的病理生理学,研究了睾酮缺乏对这一人群的各种影响,并评估了睾酮替代疗法(TRT)的优势。现有证据表明,睾酮替代疗法对 ESRD 和肾移植患者是一种安全的干预措施,在多个领域都有改善。尽管许多研究提供了宝贵的见解,但我们仍然迫切需要更大规模、高质量的前瞻性研究,以全面掌握 TRT 的细微差别,尤其是在这一弱势群体中。积极筛查和治疗睾酮缺乏症可能会带来益处,这也强调了在该领域开展进一步研究的紧迫性。
Testosterone deficiency in men with end stage renal disease and kidney transplantation: a narrative review
Testosterone deficiency is a prevalent condition that frequently affects individuals with end-stage renal disease (ESRD) and those who have undergone renal transplantation. While the etiology of this condition is complex, its implications in this population are far-reaching, impacting various domains such as endocrine profile, sexual and erectile function, bone mineral density (BMD), anemia, and graft survival following renal transplantation. Herein, we review the most recent literature exploring the pathophysiology of testosterone deficiency in ESRD and renal transplant patients, examining its diverse effects on this demographic, and assessing the advantages of testosterone replacement therapy (TRT). Existing evidence suggests that TRT is a safe intervention in ESRD and renal transplant patients, demonstrating improvements across multiple domains. Despite valuable insights from numerous studies, a critical need persists for larger, high-quality prospective studies to comprehensively grasp the nuances of TRT, especially in this vulnerable population. Proactive screening and treatment of testosterone deficiency may prove beneficial, emphasizing the urgency for further research in this area.
期刊介绍:
International Journal of Impotence Research: The Journal of Sexual Medicine addresses sexual medicine for both genders as an interdisciplinary field. This includes basic science researchers, urologists, endocrinologists, cardiologists, family practitioners, gynecologists, internists, neurologists, psychiatrists, psychologists, radiologists and other health care clinicians.