{"title":"不知道自己在服用治疗糖尿病和心血管疾病的药物","authors":"","doi":"10.1016/j.jjcc.2024.03.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Some patients with diabetes are unaware that they are prescribed medications for diabetes. The purpose of this study is to determine, using a Japanese nationwide epidemiologic database, the association between unawareness of being prescribed medication for diabetes and the risk of developing cardiovascular disease (CVD) in patients with diabetes.</p></div><div><h3>Methods</h3><p>This observational cohort study analyzed data from the JMDC Claims Database between 2005 and 2022, including 94,048 patients with diabetes treated with medications. The primary endpoint was a composite endpoint including myocardial infarction (MI), stroke, heart failure (HF), and atrial fibrillation (AF).</p></div><div><h3>Results</h3><p>We identified 7561 composite CVD endpoints during a mean follow-up of 1199 ± 902 days. Overall, 7779 (8.3 %) patients were unaware of being prescribed medications for diabetes. Those who did not know they were prescribed drugs were younger and had better glycemic control, but these individuals were at higher risk of developing combined CVD [hazard ratio (HR) 1.13, 95 % confidence interval (95 % CI) 1.04–1.22]. HRs of unawareness of being prescribed medications for diabetes were 1.33 (95 % CI 1.06–1.68) for MI, 1.13 (95 % CI 0.97–1.31) for stroke, 1.10 (95 % CI 1.00–1.21) for HF, and 1.19 (95 % CI 0.97–1.47) for AF, respectively.</p></div><div><h3>Conclusions</h3><p>In patients with diabetes taking medications for diabetes, even if they are young and have good glycemic control, unawareness of being prescribed medications for diabetes was associated with a greater risk of developing CVD. It is important that they receive adequate education from their healthcare providers to accurately identify their treatment status.</p></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unawareness of being prescribed medications for diabetes and incident cardiovascular disease\",\"authors\":\"\",\"doi\":\"10.1016/j.jjcc.2024.03.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Some patients with diabetes are unaware that they are prescribed medications for diabetes. The purpose of this study is to determine, using a Japanese nationwide epidemiologic database, the association between unawareness of being prescribed medication for diabetes and the risk of developing cardiovascular disease (CVD) in patients with diabetes.</p></div><div><h3>Methods</h3><p>This observational cohort study analyzed data from the JMDC Claims Database between 2005 and 2022, including 94,048 patients with diabetes treated with medications. The primary endpoint was a composite endpoint including myocardial infarction (MI), stroke, heart failure (HF), and atrial fibrillation (AF).</p></div><div><h3>Results</h3><p>We identified 7561 composite CVD endpoints during a mean follow-up of 1199 ± 902 days. Overall, 7779 (8.3 %) patients were unaware of being prescribed medications for diabetes. Those who did not know they were prescribed drugs were younger and had better glycemic control, but these individuals were at higher risk of developing combined CVD [hazard ratio (HR) 1.13, 95 % confidence interval (95 % CI) 1.04–1.22]. HRs of unawareness of being prescribed medications for diabetes were 1.33 (95 % CI 1.06–1.68) for MI, 1.13 (95 % CI 0.97–1.31) for stroke, 1.10 (95 % CI 1.00–1.21) for HF, and 1.19 (95 % CI 0.97–1.47) for AF, respectively.</p></div><div><h3>Conclusions</h3><p>In patients with diabetes taking medications for diabetes, even if they are young and have good glycemic control, unawareness of being prescribed medications for diabetes was associated with a greater risk of developing CVD. It is important that they receive adequate education from their healthcare providers to accurately identify their treatment status.</p></div>\",\"PeriodicalId\":15223,\"journal\":{\"name\":\"Journal of cardiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0914508724000571\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cardiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0914508724000571","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
有些糖尿病患者并不知道自己在服用治疗糖尿病的药物。本研究的目的是利用日本全国流行病学数据库，确定糖尿病患者不知道自己在接受药物治疗与患心血管疾病（CVD）风险之间的关系。这项观察性队列研究分析了 2005 年至 2022 年期间日本医疗数据中心索赔数据库中的数据，其中包括 94,048 名接受药物治疗的糖尿病患者。主要终点是一个复合终点，包括心肌梗死（MI）、中风、心力衰竭（HF）和心房颤动（AF）。在平均 1199 ± 902 天的随访期间，我们确定了 7561 个心血管疾病复合终点。总体而言，有 7779 名（8.3%）患者不知道自己在服用糖尿病处方药。不知道自己有处方药的患者更年轻，血糖控制得更好，但这些人合并心血管疾病的风险更高[危险比 (HR) 1.13，95 % 置信区间 (95 % CI) 1.04-1.22]。不知道有处方药的患者发生心肌梗死的危险比分别为 1.33（95 % CI 1.06-1.68），发生中风的危险比分别为 1.13（95 % CI 0.97-1.31），发生高血压的危险比分别为 1.10（95 % CI 1.00-1.21），发生房颤的危险比分别为 1.19（95 % CI 0.97-1.47）。对于服用糖尿病药物的糖尿病患者，即使他们年轻且血糖控制良好，也必须接受医疗保健提供者的充分教育，以准确识别他们的治疗状况。
Unawareness of being prescribed medications for diabetes and incident cardiovascular disease
Background
Some patients with diabetes are unaware that they are prescribed medications for diabetes. The purpose of this study is to determine, using a Japanese nationwide epidemiologic database, the association between unawareness of being prescribed medication for diabetes and the risk of developing cardiovascular disease (CVD) in patients with diabetes.
Methods
This observational cohort study analyzed data from the JMDC Claims Database between 2005 and 2022, including 94,048 patients with diabetes treated with medications. The primary endpoint was a composite endpoint including myocardial infarction (MI), stroke, heart failure (HF), and atrial fibrillation (AF).
Results
We identified 7561 composite CVD endpoints during a mean follow-up of 1199 ± 902 days. Overall, 7779 (8.3 %) patients were unaware of being prescribed medications for diabetes. Those who did not know they were prescribed drugs were younger and had better glycemic control, but these individuals were at higher risk of developing combined CVD [hazard ratio (HR) 1.13, 95 % confidence interval (95 % CI) 1.04–1.22]. HRs of unawareness of being prescribed medications for diabetes were 1.33 (95 % CI 1.06–1.68) for MI, 1.13 (95 % CI 0.97–1.31) for stroke, 1.10 (95 % CI 1.00–1.21) for HF, and 1.19 (95 % CI 0.97–1.47) for AF, respectively.
Conclusions
In patients with diabetes taking medications for diabetes, even if they are young and have good glycemic control, unawareness of being prescribed medications for diabetes was associated with a greater risk of developing CVD. It is important that they receive adequate education from their healthcare providers to accurately identify their treatment status.
期刊介绍：
The official journal of the Japanese College of Cardiology is an international, English language, peer-reviewed journal publishing the latest findings in cardiovascular medicine. Journal of Cardiology (JC) aims to publish the highest-quality material covering original basic and clinical research on all aspects of cardiovascular disease. Topics covered include ischemic heart disease, cardiomyopathy, valvular heart disease, vascular disease, hypertension, arrhythmia, congenital heart disease, pharmacological and non-pharmacological treatment, new diagnostic techniques, and cardiovascular imaging. JC also publishes a selection of review articles, clinical trials, short communications, and important messages and letters to the editor.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
