视网膜新生血管中 Caveolin-1 功能和机制的最新研究进展

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Current drug targets Pub Date : 2024-04-09 DOI:10.2174/0113894501310201240403065930

Rui Zhang, Yalong Dang

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引用次数: 0

摘要

:视网膜新生血管疾病的致盲率相对较高。视网膜新生血管异常是其主要特征，会损害眼睛的结构和功能，导致视力受损。Caveolin-1 是一种膜蛋白，在多种类型的视网膜细胞中都有表达，并参与视网膜新生血管的形成。本综述全面分析了全球有关洞穴素-1在视网膜新生血管中特定功能的研究。我们认为洞穴素-1的作用机制可能与相关信号通路的调控有关，并展望了调节洞穴素-1在视网膜新生血管疾病中的应用前景。

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The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization

: Retinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of action of caveolin-1 might be related to the regulation of relevant signal pathways and looked ahead the application prospects of modulating caveolin- 1 in retinal neovascularization diseases.

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.