气管吸液元基因组学揭示抗生素耐药性与非肺部败血症死亡率的关系

medRxiv - Intensive Care and Critical Care Medicine Pub Date : 2024-04-10 DOI:10.1101/2024.04.08.24305484

Héctor Rodríguez-Pérez, Laura Ciuffreda, Tamara Hernández-Beeftink, Beatriz Guillen-Guio, David Domínguez, Almudena Corrales, Elena Espinosa, Julia Alcoba-Florez, Jose M. Lorenzo-Salazar, Rafaela González-Montelongo, Jesús Villar, Carlos Flores

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引用次数: 0

摘要

背景以前对肺外败血症患者进行的基于 16S rRNA 测序的代谢组学研究发现，早期肺部菌群失调与预后不良有关。为了进一步确定这种关联，我们在此旨在利用元基因组学更好地描述这些患者肺部细菌群落的特征，并评估抗生素耐药基因（ARGs）的存在是否能解释患者死亡率较高的原因。

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Tracheal aspirate metagenomics reveals association of antibiotic resistance with non-pulmonary sepsis mortality

Background Previous metabarcoding studies based on 16S rRNA sequencing in patients with extrapulmonary sepsis have found early pulmonary dysbiosis associated with a poor prognosis. To further discern this association, here we aimed to better characterize the pulmonary bacterial communities in these patients by leveraging metagenomics and to evaluate if the presence of antibiotic resistance genes (ARGs) could explain the higher mortality of the patients.

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medRxiv - Intensive Care and Critical Care Medicine

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