具有所需特性的定制分子胶复合物

IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2024-04-17 DOI:10.1038/s41587-024-02212-4
Iris Marchal
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引用次数: 0

摘要

Degron 标签可以利用被称为分子胶的小分子触发蛋白质的快速和时间可控降解。这些分子胶诱导或稳定目标蛋白质与泛素连接酶之间的蛋白质相互作用。作为研究工具,分子胶水复合物受限于 degron 标签的大尺寸,这妨碍了与内源性蛋白质编码基因的整合。在发表于《科学》(Science)的一项研究中,Mercer 等人采用持续进化的方法,生成了亲和力高、体积小的分子胶复合物,获得了一种紧凑型降解龙,它能触发蛋白质降解,且不会产生可检测到的脱靶效应。与前代产品不同,PT-179 不会降解脱靶蛋白,因此是设计具有更佳特性的分子胶复合物的理想起点。
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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