Julian Macoveanu, Lydia Fortea, Hanne Lie Kjærstad, Klara Coello, Maria Faurholt-Jepsen, Patrick M. Fisher, Gitte Moos Knudsen, Joaquim Radua, Eduard Vieta, Sophia Frangou, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
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Unaffected first-degree relatives of patients (UR) with BD are at increased risk of developing mental disorders and may manifest cognitive impairments and alterations in brain functional and connective dynamics, akin to their affected relatives.</p><span>Methods</span><p>In this prospective longitudinal study, resting-state functional connectivity was used to explore stable and progressive markers of vulnerability i.e. abnormalities shared between UR and BD compared to healthy controls (HC) and resilience i.e. features unique to UR compared to HC and BD in full or partial remission (UR <span>n</span> = 72, mean age = 28.0 ± 7.2 years; HC <span>n</span> = 64, mean age = 30.0 ± 9.7 years; BD patients <span>n</span> = 91, mean age = 30.6 ± 7.7 years). Out of these, 34 UR, 48 BD, and 38 HC were investigated again following a mean time of 1.3 ± 0.4 years.</p><span>Results</span><p>At baseline, the UR showed lower connectivity values within the default mode network (DMN), frontoparietal network, and the salience network (SN) compared to HC. This connectivity pattern in UR remained stable over the follow-up period and was not present in BD, suggesting a resilience trait. The UR further demonstrated less negative connectivity between the DMN and SN compared to HC, abnormality that remained stable over time and was also present in BD, suggesting a vulnerability marker.</p><span>Conclusion</span><p>Our findings indicate the coexistence of both vulnerability-related abnormalities in resting-state connectivity, as well as adaptive changes possibly promoting resilience to psychopathology in individual at familial risk.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Longitudinal changes in resting-state functional connectivity as markers of vulnerability or resilience in first-degree relatives of patients with bipolar disorder\",\"authors\":\"Julian Macoveanu, Lydia Fortea, Hanne Lie Kjærstad, Klara Coello, Maria Faurholt-Jepsen, Patrick M. 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Unaffected first-degree relatives of patients (UR) with BD are at increased risk of developing mental disorders and may manifest cognitive impairments and alterations in brain functional and connective dynamics, akin to their affected relatives.</p><span>Methods</span><p>In this prospective longitudinal study, resting-state functional connectivity was used to explore stable and progressive markers of vulnerability i.e. abnormalities shared between UR and BD compared to healthy controls (HC) and resilience i.e. features unique to UR compared to HC and BD in full or partial remission (UR <span>n</span> = 72, mean age = 28.0 ± 7.2 years; HC <span>n</span> = 64, mean age = 30.0 ± 9.7 years; BD patients <span>n</span> = 91, mean age = 30.6 ± 7.7 years). Out of these, 34 UR, 48 BD, and 38 HC were investigated again following a mean time of 1.3 ± 0.4 years.</p><span>Results</span><p>At baseline, the UR showed lower connectivity values within the default mode network (DMN), frontoparietal network, and the salience network (SN) compared to HC. This connectivity pattern in UR remained stable over the follow-up period and was not present in BD, suggesting a resilience trait. 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引用次数: 0
摘要
背景躁郁症(BD)的病因与遗传因素有很大关系。在这项前瞻性纵向研究中,研究人员利用静息态功能连通性来探索易感性的稳定和渐进标记,即与健康对照组(HC)相比,易感性和躁狂症患者的共同异常,以及恢复力,即与健康对照组(HC)相比,易感性和躁狂症患者的共同恢复力。在这项前瞻性纵向研究中,研究人员利用静息状态功能连通性探讨了稳定和渐进的脆弱性标记,即与健康对照组(HC)相比,UR 和 BD 患者共有的异常,以及与健康对照组和完全或部分缓解的 BD 患者(UR n = 72,平均年龄 = 28.0 ± 7.2 岁;HC n = 64,平均年龄 = 30.0 ± 9.7 岁;BD 患者 n = 91,平均年龄 = 30.6 ± 7.7 岁)相比,UR 独有的特征。结果基线时,与 HC 相比,UR 在默认模式网络(DMN)、前顶叶网络和显著性网络(SN)中显示出较低的连接值。UR的这种连接模式在随访期间保持稳定,在BD中并不存在,这表明UR具有恢复力特质。结论我们的研究结果表明,在静息态连接中既存在与脆弱性相关的异常,也存在可能促进家族风险个体对精神病理学的复原力的适应性变化。
Longitudinal changes in resting-state functional connectivity as markers of vulnerability or resilience in first-degree relatives of patients with bipolar disorder
Background
There is a significant contribution of genetic factors to the etiology of bipolar disorder (BD). Unaffected first-degree relatives of patients (UR) with BD are at increased risk of developing mental disorders and may manifest cognitive impairments and alterations in brain functional and connective dynamics, akin to their affected relatives.
Methods
In this prospective longitudinal study, resting-state functional connectivity was used to explore stable and progressive markers of vulnerability i.e. abnormalities shared between UR and BD compared to healthy controls (HC) and resilience i.e. features unique to UR compared to HC and BD in full or partial remission (UR n = 72, mean age = 28.0 ± 7.2 years; HC n = 64, mean age = 30.0 ± 9.7 years; BD patients n = 91, mean age = 30.6 ± 7.7 years). Out of these, 34 UR, 48 BD, and 38 HC were investigated again following a mean time of 1.3 ± 0.4 years.
Results
At baseline, the UR showed lower connectivity values within the default mode network (DMN), frontoparietal network, and the salience network (SN) compared to HC. This connectivity pattern in UR remained stable over the follow-up period and was not present in BD, suggesting a resilience trait. The UR further demonstrated less negative connectivity between the DMN and SN compared to HC, abnormality that remained stable over time and was also present in BD, suggesting a vulnerability marker.
Conclusion
Our findings indicate the coexistence of both vulnerability-related abnormalities in resting-state connectivity, as well as adaptive changes possibly promoting resilience to psychopathology in individual at familial risk.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.