不对称纳扎罗夫反应的最新进展

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC Current Organic Chemistry Pub Date : 2024-04-17 DOI:10.2174/0113852728296619240321060646
Hélène Pellissier
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引用次数: 0

摘要

::纳扎罗夫反应是指在强酸的作用下,二乙烯酮环化成环戊烯酮。五元碳环在多种天然和生物活性产品中的普遍存在,促使人们大力发展高效的构建方法。特别是,通过使用手性辅助剂或手性催化剂(可以是有机催化剂、金属催化剂或多催化系统),可以实现纳扎罗夫反应的不对称版本。本综述旨在更新 2017 年发表的不对称纳扎罗夫反应领域的最新研究成果。综述分为四个部分,依次论述手性助剂的纳扎罗夫反应、有机催化的对映选择性纳扎罗夫反应、金属/硼催化的对映选择性纳扎罗夫反应以及多催化的对映选择性纳扎罗夫反应。综述的每个部分又细分为简单的不对称纳扎罗夫反应和基于纳扎罗夫的多米诺/串联反应,这些反应使得许多更复杂的功能化手性分子可以在一锅程序中合成。
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Recent Developments in Asymmetric Nazarov Reactions
:: The Nazarov reaction involves the cyclization of divinyl ketones into cyclopentenones under the influence of strong acids. The prevalence of five-membered carbocycles in a multitude of natural and bioactive products has triggered an intense development of efficient methods for their construction. In particular, asymmetric versions of the Nazarov reaction are achieved by using either a chiral auxiliary or a chiral catalyst, which can be an organocatalyst, a metal catalyst, or a multicatalytic system. This review aims to update the field of asymmetric Nazarov reactions published in 2017. It is divided into four sections, dealing successively with Nazarov reactions of chiral auxiliaries, organocatalytic enantioselective Nazarov reactions, metal/boron-catalyzed enantioselective Nazarov reactions, and multicatalytic enantioselective Nazarov reactions. Each section of the review is subdivided into simple asymmetric Nazarov reactions and Nazarovbased domino/tandem reactions, which have allowed numerous more complex functionalized chiral molecules to be synthesized in one-pot procedures.
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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