Mauro Podda, Marco Ceresoli, Marcello Di Martino, Monica Ortenzi, Gianluca Pellino, Francesco Pata, Benedetto Ielpo, Valentina Murzi, Andrea Balla, Pasquale Lepiane, Nicolo’ Tamini, Giulia De Carlo, Alessia Davolio, Salomone Di Saverio, Luca Cardinali, Emanuele Botteri, Nereo Vettoretto, Pier Paolo Gelera, Belinda De Simone, Antonella Grasso, Marco Clementi, Danilo Meloni, Gaetano Poillucci, Francesco Favi, Roberta Rizzo, Giulia Montori, Giuseppa Procida, Irene Recchia, Ferdinando Agresta, Francesco Virdis, Stefano Piero Bernardo Cioffi, Martina Pellegrini, Massimo Sartelli, Federico Coccolini, Fausto Catena, Adolfo Pisanu
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The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Failure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, <i>P</i> < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, <i>P</i> < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, <i>P</i> = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI − 0.66;3.70, <i>P</i> = 0.23).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"8 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Towards a tailored approach for patients with acute diverticulitis and abscess formation. 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In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI − 0.66;3.70, <i>P</i> = 0.23).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. 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Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case–control study
Background
This multicentre case–control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses.
Methods
This study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.
Results
Failure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, P < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, P < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, P = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI − 0.66;3.70, P = 0.23).
Conclusions
Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.
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