众包挖掘新的真菌资源，满足对新型抗生素的需求，对抗耐多药病原体

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Antibiotics Pub Date : 2024-04-17 DOI:10.1038/s41429-024-00723-5

T. S. Suryanarayanan

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引用次数: 0

摘要

抗菌药耐药性（AMR）细菌（包括多重耐药菌（MDR）、广泛耐药菌（XDR）和泛耐药菌（PDR））的进化和传播导致了健康危机，而目前能够应对这一危机的新型抗生素数量有限。利用新方法和较少使用的旧方法，对研究较少的极端环境中的真菌进行生物勘探，可以发现新型抗生素，从而控制 MDR 病原体。此外，我还提出了一种众包模式，这种模式可以大大增加发现新型抗生素以及其他治疗领域新化学型的机会，并大大降低这项工作的成本和时间。

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Crowdsourcing for mining new fungal sources for addressing the need for novel antibiotics against multidrug resistant pathogens

There are a limited number of new antibiotics to manage the health crisis caused by the evolution and spread of antimicrobial resistant (AMR) bacteria including multidrug resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resistant (PDR) ones. Bioprospecting fungi of less studied and extreme environments using new and less used older approaches could reveal novel antibiotics to manage MDR pathogens. Furthermore, I posit a crowdsourcing model which could substantially increase the chances of discovering novel antibiotics as well as new chemotypes for other therapeutic areas and considerably reduce the cost and time of this exercise.

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.